N -Acetylglucosamine-6- O -sulfotransferase (GlcNAc6ST) was cloned in the mouse and humans ( Uchimura et al. 1998b , c ). The expressed enzyme transferred sulfate to nonreducing GlcNAc but not to internally located GlcNAc. This specificity is consistent with that of the enzyme previously ...
Sulfation of this epitope on the N-acetylglucosamine (GICNAc) residue confers high-avidity L-selectin binding, and is thought to be restricted in the vasculature to sites of sustained lymphocyte recruitment. The GIcNAc-6-Osulfotransferase that installs the sulfate ester may be a key modulator of...
Major sulfated N-glycans were identified in both porcine and mouse PNS myelin, demonstrating that the 6-O-sulfation of N-acetylglucosamine (GlcNAc-6-O-sulfation) is highly conserved in PNS myelin between these species. P0 protein, the most abundant glycoprotein in PNS myelin and mutations in ...
are serine-linked linear polymers elongated as binary alternation of glucuronic acid and N-acetylglucosamine2. Regions of a growing GAG chain undergo enzymatic-mediated modifications (i.e., epimerization, N-deacetylation/sulfation, and O-sulfation) that ultimately give rise to distinct sulfation patterns...
The subtypes and gene defects are as follows: MPS III-A, heparan sulfate sulfatase; MPS III-B, α-N-acetylglucosaminidase (MPS III-B); MPS III-C, N-acetyltransferase; and MPS III-D, α-N-acetylglucosamine-6 sulfatase. Systemic findings include severe mental retardation with relatively mild ...
The initial event is the recognition of soluble lysosomal enzymes by UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (briefly phosphotransferase). This enzyme transfers N-acetylglucosaminyl phosphate to mannose residues of the α1,6 and α1,3 branches of the N-linked ...
β4Gal-T1 to -T6 exhibit activity to transfer galactose (Gal) to N-acetylglucosamine (GlcNAc) with a β1,4-linkage on N- and O-glycans and glycolipids (1, 2, 3, 4). β4Gal-T7 synthesizes the Galβ1–4Xyl structure, which occurs in the linkage portion of glycosaminoglycans (GAGs)...
N -acetylglucosamine-6- O -sulfotransferase (GlcNAc6ST) transfers a sulfate group from PAPS to an N -acetylglucosamine residue, which is usually located at the non-reducing end of glycoconjugates. It is important to note that sulfation proceeds the elongation of the glycan chain. This enzyme is...
1. An isolated nucleic acid encoding a UDP-N-Acetylglucosamine: Galactose-β1,3-N-Acetylgalactosamine-α-R β1,6 N-Acetylglucosaminyl-transferase termed C2GnT3 having glycosyltransferase activity, or a fragment thereof having glycosyltransferase activity, wherein the C2GnT3 amino acid sequence is at...
Glucosamine, N-acetylglucosamine and β-glucan compositions suitable for human or animal consumption or use are disclosed. The glucosamine, N-acetylglucosamine and β-glucan compositi