Genetic system for inducible NLRC4 inflammasome activation in vivo.aSchematic showing iOvaFla transgene insertion in theRosa26locus.bFlow cytometry analysis of bone marrow derived macrophages (BMMs) cultured from WT,Nlrc4−/−; iOvaFla andNlrc4−/−; iOvaFla; LysM-Cre+/−mice (represen...
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Drugs that selectively kill senescent cells (senolytics) improve the outcomes of cancer, fibrosis and age-related diseases. Despite their potential, our knowledge of the molecular pathways that affect the survival of senescent cells is limited. To discov
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Ann Trop Paediatr,1993,13(4):373-378 [1 15]Pulliam PN,Atria MW,Cronan l(^I.C-reactive protein in febrile children 1 to 36 months of age with clinically undeteelable serious bacterial infection.Pediatrics,2001,108 (6):1275.1279 [1 16]Isaaeman DJ,Burke BL.Utility of the sernm C....
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3. AD mice on C57BL/6JRCCHSD (seven females) received two injections from the age of 12 months, while untreated AD mice (five females) and non-AD mice (eight females) received buffer only. In addition, to test whether the injected mitochondria arrive at the brain and/or liver, these...