Tel: +1 323 442 7814; Fax: +1 323 442 7729; E-mail: xuefhuan@usc.edu Abbreviations: HSCs, hematopoietic stem cells; Gfi-1, growth factor independence-1; LSKs, Lin−Sca1+cKit+ cell population; WT, wild type; IRF, interferon regulatory factor; IFN-I, type-I interferon; PRC1, ...