CAR T cell therapy has proven effective in treating various hematological cancers. However, not all patients respond equally well to treatment. In a clinical study, researchers from the University of Leipzig Medical Center ... Apr 26, 2024 ...
Yue Wang Tianwei Lan Peng Liu ResearchOpen Access08 Apr 2025Cell Death & Disease Volume: 16, P: 263 A Real-World International Staging System (RW-ISS) for patients with newly diagnosed multiple myeloma Christian Brieghel Tobias Schmidt Slørdahl ...
projection (UMAP) showed that BME immune cells clustered by cell type without the need for further batch-effect correction (Fig.1c). A clear separation of plasma/myeloma cells from BME immune cells was apparent from the enrichment of CD138+cells (Supplementary Fig.1g, h) and the high expres...
A type of white blood cell called a plasma cell makes antibodies that fight infections in your body. When you have multiple myeloma, these cells multiply the wrong way. They let too much protein (called immunoglobulin) into your bones and blood. It builds up throughout your body and damages...
T-cell exhaustionREGULATORY T cellsCYTOTOXIC T cellsTUMOR antigensBONE marrowPurpose: Type I conventional dendritic cells (cDC1s) play a key role in priming anti-tumor cytotoxic T cells and inducing immune tolerance for self-antigens and tumor antigens. However, it remain...
Two human myeloma cell lines, amylase-producing KMS-12-PE and amylase-non-producing KMS-12-BM, were established from a patient, having the same chromosome ... Two human myeloma cell lines, KMS-12-PE and KMS-12-BM, were established from a 64-year-old woman with a non-producing type of...
On the x-axis the malignant cell type and the SNP at nucleotide 78 of the ADIR gene are depicted. MM and leukemic cells expressing the LB-ADIR-1F epitope (CT or TT) were recognized by both CTLs whereas LB-ADIR-1F–negative (CC) targets were only lysed by control allo-A2 CTLs (A)...
Introduction: Immunoglobulin (Ig) gene rearrangement is a hallmark of early B-cell development. As multiple myeloma is considered a clonal disease originating from the transformation of a single plasma cell, myeloma cells are traditional... NC Munshi,Joaquin Martinez-Lopez,V Carlton,... - 《Blood...
). The cell type assignment of the TME was done based on a Cite-seq BM reference dataset56 by using the multimodal reference mapping approach from Stuart et al.22. In brief, the cell type assignment of each sample works as follows: anchors were defined between the reference and each query...
type andCiita-knockout mice. Mice that did not receive myeloma cells served as controls for baseline level of bone density. Six weeks after myeloma cell injection, we found increased levels of M-proteins in both the knockout mice and the wild-type mice (Fig.2b), indicating establishment of...