MM is the most common cancer metastasizing to bone, with 85鈥 90% of patients developing bone disease. It is unique from other forms of metastatic bone disease, as it is purely lytic. There are a multitude of factors involved in promoting bone disease in MM; however, what remains ...
Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines.[1]MM is part of a spectrum of diseases rangi...
Nature Reviews Cancer volume 7, pages 585–598 (2007)Cite this article 12k Accesses 20 Altmetric Metrics details Key Points Multiple myeloma is a currently incurable B-cell malignancy characterized by excess monotypic plasma cells in the bone marrow in association with an excess of monoclonal ...
IL-6 overexpressed either by the myeloma cells themselves or by stromal cells in the BM appears to drive the development and maintenance of the cancer. Indeed, the binding of myeloma cells to receptors on bone marrow stromal cells stimulates the synthesis of IL-6 by the latter. As well as ...
Correspondence23 Mar 2025Bone Marrow Transplantation P: 1-3 A real-world experience of efficacy and safety of belantamab mafodotin in relapsed refractory multiple myeloma Rachel Dileo Prerna Mewawalla Hamza Hashmi CorrespondenceOpen Access10 Mar 2025Blood Cancer Journal ...
Cancer cells are well-known for their capacity to adapt their metabolism to their increasing energy demands which is necessary for tumor progression. This is no different for Multiple Myeloma (MM), a hematological cancer which develops in the bone marrow (BM), whereby the malignant plasma cells ...
8.7K Multiple myeloma is a cancer that attacks plasma cells in bone marrow, reducing the body's ability to fight infections. Learn about multiple myeloma, including the cells involved, tests, and treatments. Explore related conditions and understand which symptoms indicate multiple myeloma. Related...
Cancer cells are well-known for their capacity to adapt their metabolism to their increasing energy demands which is necessary for tumor progression. This is no different for Multiple Myeloma (MM), a hematological cancer which develops in the bone marrow (BM), whereby the malignant plasma cells ...
Myelomais the most common primarymalignancyaffecting theskeleton, with an incidence of approximately 10 per 100,000.1It is a clinically and biologically heterogeneous cancer arising from bone marrow plasma cells that evolves from a premalignant precursor condition (monoclonal gammopathy of undetermined signif...
MM is an archetype of cancer cell-stroma interactions whereby MM cells reside and metastasize systemically within the bone marrow microenvironment11. In the bone ecosystem, MM interacts closely with mesenchymal stem cells (MSCs) and other progenitor cells6,12,13,14,15 that secrete MM pro-survival...