PROGNOSISRISK assessmentPROTEIN-tyrosine kinase inhibitorsDISEASE managementPROGRESSION-free survivalThe introduction of tyrosine kinase inhibitors (TKIs) has changed the treatment paradigm of chronic myeloid leukemia (CML), leading to a dramatic improvement of the outcome of CML patients, who n...
Ofran Y and Rowe JM: Acute myeloid leukemia in adolescents and young adults: Challenging aspects. Acta Haematol 132: 292‑297, 2014.Ofran Y, Rowe JM. Acute myeloid leukemia in adolescents and young adults: challenging aspects. Acta Haematologica. 2014; 132:292-297. [PubMed: ...
6 In fact, overexpression of the anti-apoptotic B cell leukemia/lymphoma-2 (BCL-2) gene is upregulated in 84% of AML patients at diagnosis and 95% at relapse,15 and is associated with poor prognosis, lower complete remission (CR) rate, significantly shorter survival,2,16 AML cell ...
AMM is a clonal myeloproliferative disorder characterized byleukoerythroblastosis, myeloid metaplasia and varying degrees of myelofibrosis. It is a rare disease in children and they have a better prognosis than adults. Its etiology is unknown.
Related to acute myeloid leukemia:Chronic Myeloid Leukemia ThesaurusAntonymsRelated WordsSynonymsLegend: Switch tonew thesaurus Noun1. acute myeloid leukemia- acute leukemia characterized by proliferation of granular leukocytes; most common in adolescents and young adults ...
Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with an incidence of over 20 000 cases per year in the United States alone. Large chromosomal translocations as well as mutations in the genes involved in hematopoietic prolifer
Patients 鈮 60 years of age continue to have poor prognosis. Preliminary results suggest benefit from reduced-intensity a... ML Sorror,E Estey - 《Hematology》 被引量: 35发表: 2014年 Treatment of acute myeloid leukemia in older adults General—The assessment of an older adult with AML ...
However, an advanced form of CML, called blast phase CML, can arise in either lymphoid or myeloid progenitor cells. The type of cell will affect treatment. Chronic myeloid leukemia Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm (MPN). MPNs are a group of blood ...
The diagnostic criteria of MDS-5q have not changed. While recognized as factors that may potentially alter the biology and/or prognosis of the disease, the presence ofSF3B1or aTP53mutation (not multi-hit) does not per se override the diagnosis of MDS-5q. ...
Keywords: acute myeloid leukemia; PTPN11 mutations; prevalence; clinical characteristics; prognosis 1 Introduction Acute myeloid leukemia (AML) is a clonal malignant proliferative disease of primitive cells in the hematopoietic system, and whole-genome sequencing has revealed the complexity and high heteroge...