Acute myeloid leukemia (AML) is a type of blood cancer that starts in your bone marrow, which is the soft inner part of your bones where all your blood cells are made. AML usually begins in cells that turn into white blood cells but can also start in other blood-forming cells. When b...
Acute myeloid leukemia (AML) is characterized in human by a high relapse rate indicating that leukemia initiating cells are protected by its niche. However, despite our knowledge in murine models little is known about the bone marrow architecture in human and the impact of the leukemic niche on...
doi:10.3109/10428199109067639Zuiable, A.Treleaven, J. G.Powles, R. L.Aboud, H.Tiley, C.Kenny, M. W.Cavenagh, J.Taylor & FrancisLeukemia & Lymphoma
Zhou HS,Carter BZ,Andreeff M.Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia:Yin and Yang[J].Cancer Biol Med,2016,13(2):248-259.Zhou, H.S.; Carter, B.Z.; Andreeff, M. Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid ...
Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia growth-permissive and
Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia growth-permissive and
Leukemia stem cells HSCs: Hematopoietic stem cells MSCs: Mesenchymal stem cells CXCL12: C-X-C motif chemokine ligand 12 ECM: Extracellular matrix LepR: Leptin receptor MSC-Evs: Mesenchymal stem cell-derived extracellular vehicles BMAT: Bone marrow adipose tissue ...
Acute Myeloid Leukemia (AML) is a bone marrow malignancy characterized by the infiltration of the bone marrow, blood and other tissues by clonal cells of the myeloid lineage with limited or no potential for differentiation [1]. From:Leukemia Research,2022 ...
www.nature.com/scientificreports OPEN received: 28 October 2015 accepted: 17 March 2016 Published: 06 April 2016 Combined Population Dynamics and Entropy Modelling Supports Patient Stratification in Chronic Myeloid Leukemia Marc Brehme1,*, Steffen Koschmieder2,*, Maryam Montazeri1, Mhairi ...
Bone marrow necrosis masquerading as interferon toxicity in chronic myeloid leukemia[J].Leuk Lymph, 1999, 33(3-4):385-388.Chim CS, Ma SK, Lam CK (1999) Bone marrow necrosis masquerading as interferon toxicity in chronic myeloid leukemia. Leuk Lymphoma 33:385-388...