Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a ...
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitor cells and immature myeloid cells (IMCs) with a potent immunosuppressive activity against T-cell responses. In health, IMCs differentiate into mature granulocytes, macrophages and dendritic cells, and these IMCs...
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in he...
myeloid cells with the ability to suppress the cytotoxic activity of NK cells and the adaptive immune responses mediated by CD4 + and CD8 + T cells, and they are often referred to as myeloid derived suppressor cells (MDSCs), tumor promoting neutrophils or granulocytes (Sceneay et al., 2012...
Myeloid-derived suppressor cells Myeloid-derived suppressor cells(MDSCs) are earlymyeloid cellswhich are expanded in thetumor microenvironmentand suppress T-cell proliferation andcytokine production, while promoting tumor cell growth[149,150]. InMM, the number of MDSCs is increased in both peripheral ...
网络骨髓衍生抑制细胞;髓系衍生抑制细胞 网络释义
《海外直订Myeloid-Derived Suppressor Cells 髓源性抑制细胞》,作者:海外直订Myeloid-Derived Suppressor Cells 髓源性抑制细胞Brandau 著,出版社:Humana,ISBN:9781071610596。
Myeloid-derived suppressor cells (MDSCs) accumulate and differentiate through tightly regulated by diverse signaling pathways (Fig.1). Here, we highlight several key pathways, including STATs, C/EBP, and NF-κB. Numerous studies have investigated how STATs signaling pathways govern MDSCs. Targeting...
Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However...