Beta-arrestin 2, a multifunctional adaptor protein, is highly expressed in bone marrow tissues and macrophages and is involved in metabolism disorders. Here, we observed that 尾-arrestin 2 expression was significantly increased in the liver macrophages and circulating monocytes of patients with MASH ...
Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages 髓样β-抑制蛋白2耗竭通过巨噬细胞的代谢重编程减轻代谢功能障碍相关的脂肪性肝炎 网址 https://www.sciencedirect.com/science/article/pii/S155041312... ...
[beta]-arrestin 2 regulates A[beta] generation and [gamma]-secretase activity in Alzheimer's disease beta-arrestins are associated with numerous aspects of G protein-coupled receptor (GPCR) signaling and regulation and accordingly influence diverse physiol... A Thathiah,K Horre,A Snellinx,......
Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin Blood, Volume 128, Issue 14, 2016, pp. 1884-1893 Ram Vinod Roy,…, Alireza R. Rezaie View PDF Towards harmonizing guidance for genome-informed drug treatment interventions: The show ...
Lakshmikanthan V, Zou L, Kim JI, Michal A, Nie Z, Messias NC, Benovic JL, Daaka Y (2009) Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer. Proc Natl Acad Sci USA 106: 9379–9384. Lefkowitz RJ, Shenoy SK (2005) Transduction of ...
Acute myeloid leukemia (AML) is associated with poor clinical outcome and the development of more effective therapies is urgently needed. G protein-coupled receptors (GPCRs) represent attractive therapeutic targets, accounting for approximately 30% of al
-arrestin1chronic myeloid leukaemia (CML)BCR/ABLacetylationenhancer of zeste homologue 2 (EZH2)Background:β-Arrestins are scaffold proteins that interact with various cellular signals. Although β-arrestin2 mediates the initiation and progression of myeloid leukaemia, the critical role of β-arrestin1...
Questions answered in this articleBetaPowered by GenAIThis is generative AI content and the quality may vary. Learn more. How does ALKBH5 mediate the function of Ubiquitin Specific Peptidase 9x (USP9X) in Acute Myeloid Leukemia (AML)? What role does Ubiquitin Specific Peptidase 9x (USP9X) play...
Table 1. Genes differentially expressed in GATA2-estrogen receptor (ERT) vs. GFP cell line (cell proliferation) Esr1 estrogen receptor 1 (alpha) 500.3 Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 59.7 Arrdc4 arrestin domain containing 4 20.2 Cd28 CD28 antigen...