Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors. Immunol. Rev. 238:37-46. http://dx.doi.org /10.1111/j.1600-065X.2010.00963.xKondo M. Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors. Immunol...
Figure 1. Differential Expression of Lineage-Affiliated Genes in Myeloid and Lymphoid Differentiation Pathways (A) Lineage relationships of prospectively purified lineage-restricted progenitors in steady-state hematopoiesis. HSC, hematopoietic stem cells; CMP, common myeloid progenitors; CLP, common lymphoid ...
In summary, we show that the human Fallopian tube is populated by immune cells of myeloid and lymphoid lineages. We present novel findings demonstrating the presence of dendritic cells and CD56dimCD16− NK cells in the non-pregnant Fallopian tube and report that the population of immune cells...
including cancer, this balance is lost due to dramatic expansion of myeloid progenitors that fail to mature to functional inflammatory neutrophils, macrophages, and dendritic cells (DCs), thus giving rise to a decline in the antitumor effector lymphoid response. Cancer...
lineage occurs at the common lymphoid progenitor stage, indicative of early divergence of the pDC and cDC lineages. We found the transcriptional signature of a pDC precursor stage, defined here, in the IL-7Rα+common lymphoid progenitor population and identified Ly6D, IL-7Rα, CD81 and CD2 ...
Innate lymphoid cells (ILCs) are an essential component of the innate immune system in vertebrates. They are developmentally rooted in the lymphoid lineage and can diverge into at least three transcriptionally distinct lineages. ILCs seed both lymphoid and non-lymphoid tissues and are locally self-ma...
lymphoid lineage. The evasion of myeloid cells includes effects in cis, where the virus modulates the immune signaling pathways within the infected myeloid cell, and those in trans, where the virus affects somatic cells targeted by cytokines released from myeloid cells. This review presents an ...
A more restricted expression of CD30L was found in T-cell tumors that was mainly confined to neoplasms with an activated peripheral T-cell phenotype, such as T-cell prolymphocytic leukemia, peripheral T-NHL, and adult T-cell leukemia/lymphoma. In contrast, none of the T-lineage ALLs ...
Disease phenotype was established by determining the frequencies of BM or spleen cells coexpressing GFP (BCR-ABLP210) and lineage-specific cell surface antigens (myeloid: CD11b+Gr-1+; B lymphoid: CD45R+CD19+; erythroid: Ter119+; T-lymphoid: CD4+ and/or CD8+). Disease was considered prese...
We propose that the common lymphoid progenitor and common myeloid progenitor populations reflect the earliest branch points between the lymphoid and myeloid lineages, and that the commitment of common myeloid progenitors to either the megakaryocyte/erythrocyte or the granulocyte/macrophage lineages are ...