Breast and prostate cancers were used as controls because they are not associated with TET2 mutations or risk factors for cardiovascular disease. HDRM and CVARM were identified using ICD8-10 codes as defined by SEER. Relative risks (RR) for HDRM and CVARM, adjusted for age, sex and year,...
Age, sex, diagnosis codes corresponding to MDS and chronic kidney disease, medication (ESA, luspatercept, lenalidomide), clinical lab tests (hemoglobin, absolute neutrophils, platelet, blast percentage), and evidence of bone marrow biopsy were included as the predictive variables for the models. ...
Chagas diseaseimmunosuppressionBACKGROUND: Recent retrospective studies suggest myelodysplastic syndromes (MDSs) are more common than previously recognized and patients who develop transfusional dependence may be at risk for increased comorbid complications.STUDY DESIGN AND METHODS: A retrospective review was ...
Patients with thalassemia, sickle-cell disease (SCD), and myelodysplastic syndromes (MDS) receiving frequent transfusions require chelation therapy to prevent complications of iron overload. Deferoxamine (DFO) is an effective iron chelator that has been shown to reduce the morbidity and mortality ...
Altogether, MDS is less frequent in Asia compared to Western population, but the disease may be more severe as it appears earlier. To go further, we analyzed the distribution of MDS subtypes. 2.2. Asian Population is More Prone to Develop Severe MDS Subtypes 2.2.1. Subtype Distribution We ...