In the central nervous system (CNS), oligodendrocytes myelinate multiple axons; in the peripheral nervous system (PNS), Schwann cells (SCs) myelinate a single axon. Why are the myelinating potentials of these glia so fundamentally different? Here, we find that loss of Fbxw7, an E3 ubiquitin...
Schwann cellsSkin biopsyThe human skin is richly innervated by nerve fibers of different calibers and functions, including thickly myelinated large fibers that act as afferents for mechanoreceptors in the dermal papillae...doi:10.1007/978-1-4939-7649-2_24Mario A. SaportaRenata...
We would like to thank Dr. James L. Salzer (New York University) for instrumental training on the world of myelinating Schwann cells neuronal cocultures. We are also grateful to Dr. Steven Einheber (Hunter College New York), Dr. Angelo Quattrini (San Raffaele Scientific Institute), and Dr....
Tst-1/SCIP/Oct-6, a POU domain transcription factor, is transiently expressed by developing Schwann cells and is required for their normal development into a myelinating phenotype. In tst-1/scip/oct-6-null sciatic nerves, Schwann cells are transiently arrested at the "promyelinating" stage, ...
An electron microscopic study indicated that these Na x-positive cells were non-myelinating Schwann cells. In the lung, Na x-positive signals were also observed in the alveolar type II cells, which actively absorb sodium and water to aid gas exchange through the alveolar surface. It was thus...
H., 1997. Serotonin receptors expressed by myelinating Schwann cells in rat sciatic nerve. Brain Research 753, 299-308.Yoder EJ, Tamir H, Ellisman MH (1997). Serotonin receptors expressed by myelinating Schwann cells in rat sciatic nerve. Brain Res 753: 299-308....
Publication Targeted knock-down of cellular prion protein expression in myelinating Schwann cells does not alter mouse prion pathogenesis S. Halliez, N. Chesnais, G. Mallucci, M. Vilotte, C. Langevin, E. Jaumain, H. Laude, J.-L. Vilotte, V. Beringue ...
Schwann cellMyelinating Schwann cells control the number of neurofilaments and elevate the phosphorylation state of neurofilaments in the axon, eventually leading to the typical large axon caliber. Conversely, absence of myelin leads to lower amounts of neurofilaments, reduced phosphorylation levels, ...
Replication of prions in Schwann cells is viewed as a potentially important mechanism for efficient prion spread along nerves. Here we used a Cre-loxP mouse transgenetic approach to disrupt host-encoded prion protein (PrP(C)) specifically in myelinating Schwann cells. Despite the use of infection...
Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers.doi:10.1002/jnr.24757Paola Bargagna‐MohanGwendolyn SchultzBruce RheaumeEphraim F. TrakhtenbergPaul RobsonSonali Pal‐GhoshMary Ann Stepp...