Schwann cells, the myelin-forming cells of the PNS, are attractive candidates for remyelination therapy as they can remyelinate CNS axons. Yet their integration in CNS tissue appears hampered, at least in part, by their limited motility in the CNS environment. As the polysialylated (PSA) ...
In the central nervous system (CNS), oligodendrocytes myelinate multiple axons; in the peripheral nervous system (PNS), Schwann cells (SCs) myelinate a single axon. Why are the myelinating potentials of these glia so fundamentally different? Here, we find that loss of Fbxw7, an E3 ubiquitin...
Previous in vitro studies demonstrated that Nectin like 4 (Necl-4, also known as cell adhesion molecule Cadm-4 or SynCAM-4) plays an essential role in axonal myelination by Schwann cells in the peripheral nervous system (PNS). However, the role of Necl-4 protein in axonal myelination in...
Through systematic quantification of ZIKV infected cells in myelinating cultures, we found that ZIKV infection is enhanced in the absence of the type I interferon responses and that CNS cells are considerably more susceptible to infection than PNS cells. In particular, we demonstrate that CNS axons...
We would like to thank Dr. James L. Salzer (New York University) for instrumental training on the world of myelinating Schwann cells neuronal cocultures. We are also grateful to Dr. Steven Einheber (Hunter College New York), Dr. Angelo Quattrini (San Raffaele Scientific Institute), and Dr...
Previously, we identified non-muscle myosin II (NMII) as a key regulator of glial cell differentiation and myelin formation in both the PNS and the CNS6. NMII is necessary for the ensheathment of axons by Schwann cells (SC) and its inhibition impairs SC differentiation and myelination6,7,...
Endoplasmic reticulum stress and the unfolded protein response in disorders of myelinating glia. Myelin is vital to the proper function of the nervous system. Oligodendrocytes in the CNS and Schwann cells in the PNS are the glial cells responsible for ... Clayton,Benjamin,L L.,... - 《Brain...
Gap junctions mediate intercellular communication among Schwann cells in the PNS, and among oligodendrocytes and between oligodendrocytes and astrocytes in the CNS. Reflexive gap junctions mediating transfer between different regions of the same cell promote communication between cellular compartments of myelin...
Coordination of a complex network of the extrinsic and intrinsic regulatory pathways promotes the maturation of myelinating cells in the CNS1–3. The mammalian-target-of-rapamycin (mTOR), a serine/ threonine protein kinase, is a central regulator of the cell growth and necessary for maintenance ...
Myelinating Schwann cells determine the internodal local- ization of Kv1.1, Kv1.2, Kvbeta2, and Caspr. J. Neurocytol. 28:333-347. http://dx.doi.org/10.1023/A:1007009613484Arroyo EJ, Xu YT, Zhou L, Messing A, Peles E, Chiu SY, Scherer SS (1999) Myelinating Schwann cells determine ...