In vertebrates, oligodendrocytes (OLs) are glial cells of the central nervous system (CNS) responsible for the formation of the myelin sheath that surrounds the axons of neurons. The myelin sheath plays a crucial role in the transmission of neuronal information by promoting the rapid saltatory cond...
[22,23]. Using affinity-precipitation assays, in which active GEFs preferentially bind to guanine-nucleotide-free GTPases whereas active GAPs bind to guanosine-triphosphate-binding GTPases [16,17,18,19], we found CCZ1 and TBC1D5 activities in FBD-102b cell lysates transfected with EPRS1 ...