The objectives of this current review are to: (1) provide a comprehensive analysis of findings in the literature that investigate the nature of changes in ICM across a variety of psychiatric disorders, including SCZ, BD, obsessive compulsive disorder (OCD), and MDD; (2) provide a critical ...
We validated experimentally that expression of the transcription factor myt1 (myelin transcription factor 1) and inner nuclear membrane integral proteins lbr (lamin B receptor) were critical for the development of motor neurons and neural progenitor maintenance, respectively. We anticipate that the ...
Promoting remyelination may be an effective therapeutic strategy for various disorders that are characterized by a loss of myelin, including multiple sclerosis. In this Review, Franklin and ffrench-Constant discuss recent developments in our understandin
Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus. Neurobiol Learn Mem. 2020;167:107136. Article CAS PubMed Google Scholar Huang C, Wang...
Acta Neuropathologica Communications https://doi.org/10.1186/s40478-023-01554-5 (2023) 11:56 Acta Neuropathologica Communications REVIEW Myelin in Alzheimer's disease: culprit or bystander? Open Access Michel Maitre1* , Hélène Jeltsch-David1,2 , Nwife Getrude Okechukwu1 , Christian...
Inhibiting extracellular vesicles formation and release: a review of EV inhibitors. J Extracell Vesicles. 2020;9:1703244. Article CAS PubMed Google Scholar Fadda E, Negro A, Facci L, Skaper SD. Ganglioside GM1 cooperates with brain-derived neurotrophic factor to protect dopaminergic neurons from ...
With this review we provide an updated understanding of this model, by showcasing two distinct yet overlapping modes of action for cuprizone-induced demyelination; 1) damage originating from within the oligodendrocyte, caused by mitochondrial dysfunction or reduced myelin protein synthesis. We term ...
This review focuses on the function(s) of the different SMases in living cells. While both lysosomal and non-lysosomal pathways that ensure SM hydrolysis in intact cells can be distinguished, the precise contribution of each of these SM-cleaving enzymes to the production of ceramide as a ...
A review of the fast-developing MRI techniques that are sensitive to changes in white matter and myelin,in particular, such asdiffusion tensor imaging,magnetization transferimaging, and myelin water imaging, is beyond the scope of this chapter and the reader is referred to a comprehensive review ...
Bronstein’s review (pp 552–557) highlights recent findings that there are many more ‘tetraspan’ integral membrane proteins associated with the myelin membrane than was previously thought, and that some of these myelin proteins may have been recruited from functions outside of the nervous system...