Elucidation of marine fungi derived anthraquinones as mycobacterial mycolic acid synthesis inhibitors: an in silico approachMarine fungiAnthraquinonesMycobacterium tuberculosisPharmacokineticsDrug likenessMolecular dockingTuberculosis (TB) is a leading cause of mortality amongst infectious d...
Mycolic acid is a crucial compound found in the cell walls of certain bacteria, such as Mycobacterium tuberculosis, aiding in resistance against hydrophobic drugs and dehydration. It is synthesized through two main pathways, FAS-1 and FAS-II, involving fatty acid synthesis and elongation processes....
The soil environment from where actinomycetes can be isolated contains many different microorganisms5. Actinomycetes respond to environmental factors including biogenic factors of other microorganisms4. We previously reported that a group of mycolic acid-containing bacteria (MACB; e.g.Tsukamurella pulmonisT...
Furthermore, these high resolution structures, which are the first of an enzyme catalyzing synthesis of a cyclopropane ring to a lipid acceptor to be presented, are invaluable for rational-drug design against these new targets in mycolic acid biosynthesis. EXPERIMENTAL PROCEDURES Cloning, Protein ...
By data mining in the sequence of the Corynebacterium glutamicum ATCC 13032 genome, six putative mycolyltransferase genes were identified that code for proteins with similarity to the N-terminal domain of the mycolic acid transferase PS1 of the related C. glutamicum strain ATCC 17965. The genes ...
Carotenogenesis in Nocardioform actinomycete Rhodococcus rhodochrous was investigated using carotenogenesis mutants and inhibitors, and a postulated carotenogenesis pathway was proposed. At the end of the synthesis, fatty acid or mycolic acid was esterified by different esterases to the same C-6 hydr...
Tanya Parish3,6, Nathalie Eynard1, Mamadou Daffé1, Roland Brosch 2 & Annaïk Quémard1* The fatty acid synthase type II (FAS-II) multienzyme system builds the main chain of mycolic acids (MAs), important lipid pathogenicity factors of Mycobacterium tuberculosis (Mtb). ...
Mycolic acid synthesisMolecular dockingADMETMolecular dynamicsTuberculosis (TB) caused byMycobacterium tuberculosis(Mtb) remains a major global health threat. The treatment of TB is hampered by the emergence of multidrug resistance, so there is an urgent need to discover new anti-tubercular agents. ...
ATP provoked activation in mycolic acid synthesis in the presence of small quantities of the supernatant whereas it had no stimulant effect in the absence of the supernatant. In view of the results of partial characterization of the promoting substance(s), it is assumed that the undefined ...
Partial recovery of mycolic acid synthesis in the presence of TAC or SRI-224 in strains overexpressing the CMAS genes.Anuradha, AlahariXavier, TrivelliYann, GuérardelLynn, G. DoverGurdyal S., BesraJames C., SacchettiniRobert C., Reynolds...