Mycobacterium tuberculosis, the causative agent of TB, is the most devastating of all human pathogens. For roughly ten thousand years of human history, tuberculosis (also known as consumption or the white plague) has been a constant cause of mortality. It was the major cause of death in ...
In addition, complex lipids, such as PDIMs, have been shown to interact with host cells and participate in the virulence and pathogenesis of M. tuberculosis (22, 57). This suggests that the expression level of mtFabH or regulation of its activity by phosphorylation may also be a determinant...
Pulmonary tuberculosis, caused by Mycobacterium tuberculosis, is one of the most persistent diseases leading to death in humans. As one of the key targets during the latent/dormant stage of M. tuberculosis, isocitrate lyase (ICL) has been a subject of interest for new tuberculosis therapeutics. ...
Additionally, RIPK3 can be activated to induce necroptosis by the cytoplasmic DNA sensor Z-DNA binding protein 1 (ZBP1; also known as DAI or DLM1) [33] and downstream of Toll-like receptors by TIR domain-containing adapter-inducing interferon-β (TRIF) [34]. A function of necroptosis in...
In most cases, host immune responses can prevent the proliferation ofM. tuberculosis, but bacteria can persist asymptomatically and indefinitely in the host, leading to what is known as a latent TB infection (LTBI). Individuals with LTBIs cannot spread the pathogen to others as the ba...
1988. Characterisation of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG. Infect Immun, 56: 3046–3051. Google Scholar Adindla, S., Guruprasad, K., Guruprasad, L. 2004a. Three-dimensional models and structure analysis of corynemycolyltransferases in...
Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors Glutamine synthetase (GS, EC 6.3.1.2; also known as gamma-glutamyl:ammonia ligase) catalyzes the ATP-dependent condensation of glutamate and ammonia to for... MT Nilsson,WW Krajewsk...
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, carries different virulence factors, which allow proliferation of the pathogen in the host cell, cell-to-cell spread, and evasion of immune response. Among the most known virulence factors, phospholipases C (PLCs) stand out in...
Mycobacterium tuberculosis (M. tb) is reported to be transmitted from animals to humans or vice versa. Except for humans, who are known as natural reservoir hosts for M. tb, various kinds of animals, such as elephants, nonhuman primates, psittacine birds, cattle, and tapirs, have been report...
The Mycobacterium tuberculosis RNA polymerase (MTB RNAP) is an attractive therapeutic target, as evidenced by the fact that inhibitors of RNAP are very effective bactericidals1,2. Several bacterial RNAP inhibitors have been identified over the last few decades; however, only two have been used cl...