Multi drug resistant tuberculosis (MDR-TB) is defined as Mtb infection that shows resistance to isoniazid (INH) and Rifampicin (RMP). From:Journal of Molecular Structure,2022 Also in subject areas: Agricultural
Mycobacterium tuberculosis, the causative agent of TB, is the most devastating of all human pathogens. For roughly ten thousand years of human history, tuberculosis (also known as consumption or the white plague) has been a constant cause of mortality. It was the major cause of death in ...
M. tuberculosis has coevolved with humans [3], thereby developing immune-evasion strategies for prolonged survival and persistence. This necessitates the development of better vaccines, diagnostics, and treatments for combating the pathogen. TB was also known as consumption before its causative agent ...
Additionally, RIPK3 can be activated to induce necroptosis by the cytoplasmic DNA sensor Z-DNA binding protein 1 (ZBP1; also known as DAI or DLM1) [33] and downstream of Toll-like receptors by TIR domain-containing adapter-inducing interferon-β (TRIF) [34]. A function of necroptosis in...
Pulmonary tuberculosis, caused by Mycobacterium tuberculosis, is one of the most persistent diseases leading to death in humans. As one of the key targets during the latent/dormant stage of M. tuberculosis, isocitrate lyase (ICL) has been a subject of interest for new tuberculosis therapeutics. ...
The use of internal CRISPR diversity forM. tuberculosiscomplex genotyping A CRISPR locus, also called direct repeat (DR) region or “internal CRISPR”, is present in almost all MTBC strains (Fig.1A). As previously mentioned, CRISPR locus was identified inM. tuberculosisas early as 1993 [5] an...
M.tuberculosisandpulmonaryTBhadspreadthroughouttheknownworld. WhatareMycobacteria? Tuberculosiscomplexorganismsare: Obligateaerobesgrowingmostsuccessfullyintissueswithahigh oxygencontent,suchasthelungs. Facultativeintracellularpathogensusuallyinfectingmononuclear
tuberculosis. Bioinformatics analysis have indicated that LprN is also a cell surface associated protein. Therefore it is possible that SNP observed in this gene could be translated into antigenic variation in the LprN protein to facilitate the intracellular survival of mycobacteria. In contrast, the...
Tuberculosis is a devastating and a deadly disease despite the novel advances in its diagnostic tools and drug therapy. Drug resistant Mycobacterium contributes a great share to tuberculosis mortality. Status of drug resistance and patients’ awareness t
In addition, complex lipids, such as PDIMs, have been shown to interact with host cells and participate in the virulence and pathogenesis of M. tuberculosis (22, 57). This suggests that the expression level of mtFabH or regulation of its activity by phosphorylation may also be a determinant...