作为重要促癌基因,c-Myc在包括三阴性乳腺癌在内的多种肿瘤组织存在过表达。c-Myc对三阴性乳腺癌的进展和转移具有重要作用,参与调控细胞周期、重塑细胞代谢,并通过肿瘤-免疫互作影响肿瘤微环境[2]。已有研究表明,c-Myc可通过PD-L1表达促进免疫逃逸[3],靶向c-Myc和PD-L1或可对三阴性乳腺癌带来疗效的提高[4]。...
c-Myc可以通过调节PD-L1的表达,增强肿瘤对机体免疫应答的抑制作用。Xu等[10]发现肝癌中PD-L1在翻译阶段受到c-Myc的调节,增强PD-1/PD-L1介导的免疫逃逸,在c-Myc依赖的肿瘤进展中发挥关键作用[11];Casey等[12]研究显示,无论体内或体外实验,c-Myc失活均会导致PD-L1 mRNA水平和蛋白质水平及免疫荧光快速下调。P...
有骨髓侵犯的DLBCL患者CMYC及PD-L1的表达阳性率显著高于Ann Arbor分期Ⅰ~Ⅱ期及无骨髓侵犯者(P均<0.05);预后不良组中CMYC及PD-L1的表达阳性率显著高于预后良好组,且Ann Arbor分期为Ⅲ~Ⅳ的患者占比显著高于预后良好组(P<0.05);Logistic回归分析发现,CMYC阳性,PD-L1阳性及Ann Arbor分期均是DLBCL预后不良的独立...
结果:50例DLBCL中瘤细胞PD-L1、p53、C-myc阳性率分别为42%(21/50)、18%(9/50)、14%(7/50),PD-L1的表达与Hans分型有关(P<0.05),而与患者性别、年龄、发病部位、Ki-67指数、AnnArbor分期、国际预后指数(IPI)评分、血清乳酸脱氢酶(LDH)水平、ECOG评分及有/无B症状无关(P>0.05);p53、C-myc表达与DLBC...
但PD-L1抑制剂的功效在许多实体瘤癌症患者中的效果是有限的,研究发现,在肺腺癌(LUAD)患者体内,除了mRNA PD-L1,LncRNA PD-L1可以通过可变剪切实现免疫检查点抑制,IFNγ能促进mRna PD-L1和ncRNA PD-L1的表达。PD-L1-Lnc一旦生成,通过直接结合c-Myc并激活c-Myc转录活性,减少肿瘤细胞凋亡,促进LUAD患者肿瘤细胞...
引用排行 高级检索 专刊专栏 投稿指南 期刊订阅 出版声明 联系我们 English MYC/BCL2双表达大B细胞淋巴瘤中PD-L1的表达及其临床意义王平, 杨文秀, 周杰, 冯江龙, 林超群 Expression of PD-L1 and Its Clinical Significance in MYC/BCL2 Double-expression Large B Cell Lymphoma WANG Ping, ...
抑制CDK7使非小细胞肺癌对p38α抑制剂增敏。此外,THZ1通过抑制MYC活性抑制PD-L1的表达。THZ1通过招募浸润的CD8+T细胞增强抗肿瘤免疫,并与抗PD-1治疗有协同作用。CDK7/MYC/PD-L1信号和浸润的T细胞状态共同将NSCLC患者分为不同的危...
Journal of Hematology & Oncology https://doi.org/10.1186/s13045-020-00926-x (2020) 13:99 RESEARCH Open Access CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer Jian Wang1† , Ruiguang Zhang1†, Zhenyu Lin1, Sheng...
Mechanistically, TRMT61A-mediated tRNA-m 1 A modification promotes MYC protein synthesis, upregulating programmed death-ligand 1 (PD-L1) expression. Moreover, m 1 A modification levels were also elevated in tumors treated with oncolytic herpes simplex virus (oHSV), contributing to reactive PD-L1...
Acetate, a precursor of acetyl-CoA, is instrumental in energy production, lipid synthesis and protein acetylation. However, whether acetate reprogrammes tumour metabolism and plays a role in tumour immune evasion remains unclear. Here, we show that aceta