Myc-driven chromatin accessibility promotes Cdc45/GINS recruitment to resident MCMs, and activation of CMGs. Myc-Box II, which is necessary for Myc-driven transformation, is required for Myc-induced chromatin accessibility, Cdc45/GINS recruitment, and replication stimulation. Myc interactors GCN5, ...
Differentiation Association www.nature.com/cdd Mnt modulates Myc-driven lymphomagenesis Kirsteen J Campbell1,4,5, Cassandra J Vandenberg1,2,5, Natasha S Anstee1,2, Peter J Hurlin3 and Suzanne Cory*,1,2 The transcriptional represser Mnt is a functional antagonist of the proto-oncoprotein Myc....
In contrast, Rnf4 deletion extended the healthy lifespan of mice expressing an oncogenic c-myc transgene. Rnf4 activity is essential for normal DNA replication, and in its absence, there was a failure in ATR-CHK1 signaling of replication stress. Factors that normally mediate replication fork ...
Lastly, we found that DLBCLs with high MYC protein expression had inferior overall survival when treated with R-CHOP. In conclusion, the IHC method described herein can be used to readily identify the biologically and clinically distinct cases of MYC-driven DLBCL, which represent a clinically ...
MYC-driven MB has a particularly poor prognosis and would greatly benefit from more effective therapies. We used an animal model of MYC-driven MB to ... Yanxin,Pei,Kun-Wei,... - 《Cancer Cell》 被引量: 46发表: 2016年 Checkpoint kinase 1 expression is an adverse prognostic marker and th...
Vitamin B5 Supports Oncogenic Metabolism in MYC-Driven Breast Cancer doi:10.1158/2159-8290.CD-RW2023-185Pantothetic acid is required for metabolic activity that supports MYC-driven breast tumor growth.Cancer Discovery
Using MYC-driven medulloblastoma cells, we examined the physical interaction between PRMT5 and MYC by co-immunoprecipitation and co-localization experiments. To determine the functional role of PRMT5 in MYC-driven medulloblastoma, PRMT5 was knocked-down in MYC-amplified cells using siRNA and the ...
Novel Drug Combination Inhibits Growth of MYC-driven MedulloblastomaMegan Garlapow, PhD
C-Myc-Driven and PRMT5-Dependent Regulation of Multiple Myeloma Cell Proliferation through TNRC6B Gene 来自 ResearchGate 喜欢 0 阅读量: 117 作者:P Xu,G Dan,B Chen,Q Zhao,J Ouyang 摘要: Objective: The protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetrical bimethylation of ...
Protein biosynthesis downstream of mTORC1 plays an important role in MYC-driven oncogenesis with translation inhibitors garnering increasing therapeutic attention. The germinal center B-cell oncogene UCHL1 encodes a deubiquitinating enzyme that regulates the balance between mTOR complexes by disrupting mTOR...