目的 探讨核因子-kB(NF—kB)和c—myc在尖锐湿疣皮损角质形成细胞中的表达。方法 采用原位杂交方法检测尖锐湿疣50例,确定为HPV 6/11阳性:采用免疫组化En Vision二步法检测50例尖锐湿疣患者皮损和25例正常人皮肤(包皮)中NF—kB和c—myc的表达及分布。结果 ①与正常人皮肤对照组相比,尖锐湿疣皮损角质形成细胞中NF...
Tat-Myc蛋白质治疗正是利用肿瘤新生抗原,通过抑制癌症发生机理中发挥重要作用的IL-6/JAK/STAT3及NF-kB信号通路,直接结合于MyD88和IKKa,减少下游炎性细胞因子IL-6、TNF-a的释放,同时增加CD8+T细胞的表达,降低MDSC、PD-L1等免疫抑制性细胞和因子的表达,以此调节肿瘤微环境,抑制肿瘤细胞生长。 此外该疗法还能够针对癌...
Compared to 6-month-old Hi-Myc mice, the Luminal MYC 1 cells in 10-month-old Hi-Myc had downregulation of multiple pro-inflammatory pathways, including TNFA signaling via NFKB, inflammatory response, interferon gamma response, and interferon alpha response, with several genes being MYC ...
of apoptosis correlated with down-regulation of nuclear factor-kappaB (NF-kappaB) survivin, bcl-xL, XIAP, cIAP1, cIAP2, cylin D1, and c-myc. XN... KB Harikumar,AB Kunnumakkara,KS Ahn,... - 《Blood》 被引量: 202发表: 2009年 Maintenance of NF-κB/Rel and c-myc expression during...
The oncogene MYC is dysregulated in a host of human cancers, and as an important point of convergence in multitudinous oncogenic signaling pathways, it plays a crucial role in tumor immune regulation in the tumor immune microenvironment (TIME). Specifica
NF-kB elements mediate control of a number of important growth regulatory genes (rev. in Baeuerle, 1991). We have identified two functional NF-kB elements within the murine c-myc gene. The upstream regulatory element or URE is located -... H Lee,M Wu,FA La Rosa,... - Springer Berli...
探讨胃癌及癌前病变中NF—KB亚单位p65蛋白和c—myc蛋白的表达及相互关系。方 法 用免疫组化法检测41例胃癌及25例相应非癌组织的p65和c-myc蛋白。结果 (1)正常胃粘膜一肠 型化生一不典型增生一胃癌中,两种蛋白的阳性表达率渐次升高,且增生组、胃癌组与正常组相比差异分别 ...
Background: Activation of NF-kB pathways are a hallmark feature of TCL and HL, making proteasome inhibition an attractive therapeutic target. Previous studies have demonstrated prominent in vivo efficacy of ixazomib, an oral proteasome i... FC Passero,R Dashnamoorthy,A Beheshti,... - 《Blood》...
The transcription factor nuclear factor-κB (NF-κB), becomes overtly functional inchronic lymphocytic leukemia(CLL). Its functions include regulation of a variety of main antiapoptotic proteins and oncogenes, such as c-FLI, Bcl2, MCL1 and XIAP. It is worth mentioning that the NF-κB-activated...
(NF-kB). This cytokine leads to signal transducer and activation of transcription 3 (STAT3) signaling pathway activation, which ultimately triggers the accumulation of MDSCs in the TME of lung215,216,217and pancreatic218,219,220tumors. In this regard, pharmacological inhibition of IL-6 in KRAS...