Recent studies have identified upregulation of the dyskeratosis congenita 1 ( DKC1) gene in association with various sporadic cancers. Whole genome analyses have suggested that DKC1 may be regulated by the c-MYC oncoprotein. c-MYC is among the most commonly deregulated proteins in human cancer. ...
Therefore, we took neuroblastoma as an entry point to summarize the potential mechanism of N-Myc regulation on the cell cycle, and also considered the regulation network in other tumor cells, in an attempt to complete the regulatory network of N-Myc on the cell cycle. The MYCN gene is an ...