Here, we demonstrate that the TERB1 MYB domain has lost its canonical DNA-binding activity. The analysis of Terb1 point mutant mice expressing TERB1 lacking its MYB domain showed that the MYB domain is dispensable for telomere localization of TERB1 and the downstream TERB2-MAJIN complex, the ...
The cavity in the hydrophobic core of Myb DNA- binding domain is reserved for DNA recognition and trans- activation. Nat Struct Biol 3, 178–187. Pabo CO, Sauer RT (1992). Transcription factors: structural families and principles of DNA recognition. Annu Rev Bio- chem 61, 1053–1095. Paz...
⑴ 死亡配体(death ligands)结合DR(死亡受体)而促发的凋亡,这些配体包括TNF, FasL,TRAIL, Apo3L,也称为死亡因子,相应的死亡受体包括TNF-R, Fas, CD40, OX40, 4-1BB,它们的胞内区都具有一约80个氨基酸残基组成的保守的蛋白结合域,是传导细胞死亡信号所必须的,称之为死亡功能域(death domain,DD) ;(2)Fas...
•Structureandevolution •MYBproteinsarecharacterizedbyahighlyconservedDNA-bindingdomain:theMYBdomain（consistsofuptofourimperfectaminoacidsequencerepeats(R)ofabout52aminoacids,eachformingthreea–helices).•MYBproteinscanbedividedintodifferentclassesdependingonthenumberofadjacentrepeats(one,two,threeorfour)•...
其中,MYB结合域是MYB蛋白的保守结构域,具有与DNA结合的能力,从而调控基因的表达。而BHLH结合域是MYB结合域中的一种类型,在MYB基因中起着至关重要的作用。 BHLH结合域序列是一段特定的氨基酸序列,通常由约60个氨基酸组成,其中的核心序列为“DNA-binding domain”。这个序列具有与DNA结合的能力,从而调控基因的表达。
在c2MYB的羧基端,还有一个负调节区 (negative regulatory domain , NRD) ,此区域的缺失 或者其中某些部位的突变,经常会使转录激活功能 增强。NRD还可能与分子内部的MYB区域存在 着某种相互作用7。 图1c2MY B结构示意图 R13 : 3个串联的、 不完全重复 8、的MYB区 TA:转录激活 NRD:负调节区 通过对几种不同...
of 244 soybean-typical R2R3-MYB domains was performed with ClustalW (for full representation of the alignment, seeAdditional file 2). The bit score indicates the information content for each position in the sequence. Asterisks indicate the conserved tryptophan residues (Trp) in the MYB domain. ...
Changes in the duration, quality and intensity of light affect flowering time. Compared with the effects of light duration and quality, less is known about the effects of light intensity on flowering. Here we describe two paralogous single Myb domain genes, MYB-RELATED PROTEIN 1 (MYR1) and ...
•Structureandevolution •MYBproteinsarecharacterizedbyahighlyconservedDNA-bindingdomain:theMYBdomain（consistsofuptofourimperfectaminoacidsequencerepeats(R)ofabout52aminoacids,eachformingthreea–helices).•MYBproteinscanbedividedintodifferentclassesdependingonthenumberofadjacentrepeats(one,two,threeorfour)•...
MYB domain. Synonymous nucleotide substitution (dN/dS) analysis showed that the soybean MYB DNA-binding domain is under strong negative selection. The chromosome distribution pattern strongly indicated that genome-wide segmental and tandem duplication contribute to the expansion of soybean MYB genes. In...