A less abundant subtype of AS is represented by mutually exclusive exon (MXE) splicing. MXEs are characterized by splicing of exons in a coordinated manner such that two or more splicing events are not independent. As the name “mutually exclusive” indicates, exactly one out of two exons (...
Mutually exclusive splicing of exons is a mechanism of functional gene and protein diversification with pivotal roles in organismal development and diseases such as Timothy syndrome, cardiomyopathy and cancer in humans. In order to obtain a first genomewide estimate of the extent and biological role ...
Abbreviations: AS, alternative splicing or alternatively spliced; MXE, mutu- ally exclusive exon; EST, expressed sequence tag; NMD, nonsense mediated mRNA decay; ORF, open reading frame; Dscam, Drosophila Down Syndrome Cell Adhesion Molecule. ...