"We found that targeting the unusual slipped-DNA structures, which are critical to ongoing mutations in patient tissues, allowed us to reverse the size of repeat expansion mutations. Since longer expansions over time are directly associated with more severe disease, our findings offer hope for the ...
One of the most common causative genes is epidermal growth factor receptor (EGFR), which is a therapeutically targetable driver mutation in non-small cell lung cancer.4 Recently, driver mutations in Kirstine rat sarcoma viral oncogene homolog (KRAS), human epidermal growth factor receptor 2 (HER2...
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In addition, concentrations of retinol, retinyl esters, retinoic acid, RBP, TTR, α-tocopherol, β-carotene, and zinc were measured; the relative-dose-response-test and fat absorption test were administered; and mutations in the RBP and TTR genes were analyzed. Informed consent was obtained ...
In addition, investigation on epistatic interaction revealed significant interactions between D7Got23 and D3Rat78 and between D7Got23 and D14Mit4. Results suggested that a modified locus on Chr 7 was mainly responsible for the variance of pigmentary disorder between AGH-Ednrbsl rats and LEH-...
The functional properties of human NaCT are different from the rat and mouse transporters. The human NaCT has a Km for citrate around 600 μmol/L and functions as a citrate trans- porter (5). In contrast, the rat and mouse NaCT have Km values for citrate 20–50 μmol/L and broad ...
The present invention provides novel polypeptide and protein variants of fibroblast growth factor 21 (FGF21) and pharmaceutical compositions comprising FGF21 polypeptide and protein variants.Inventors: Boettcher, Brian R. (Winchester, MA, US) Caplan, Shari L. (Lunenburg, MA, US) Daniels, Douglas...
Rat cDNAs for GluN1-1a (GenBank accession number U08261; hereafter GluN1) GluN2A (GenBank accession number D13211), and GluN2B (GenBank accession number U11419) were used for NMDA receptor expression in HEK293T cells. As previously described [28], the DNA construct for expression of ...
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