The meaning of MUTATION is a significant and basic alteration : change. How to use mutation in a sentence.
Mutations contribute to genetic variation within species. Mutations can also be inherited, particularly if they have a positive effect. For example, the disorder sickle cell anaemia is caused by a mutation in the gene that instructs the building of a protein called hemoglobin. This causes the red...
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
T-cells mediate what is termed cell-mediated immunity, while B-cells differentiate into antibody-producing cells. Although both subclasses of lymphocytes (i.e., the T- and B-cells) are functionally related to the other member of the WBC class (i.e., the granulocytes) in that they provide...
Possible resistance mechanisms were examined by investigating the effect of synergists (Fig. 1C). In the 7th generation, in which all individuals contained the A302S mutation, synergists showed significant effects on fipronil toxicity and lowered the resistance ratios (RR) from 23.2-fold to ...
The effect of SCN1A mutations on patient-derived GABAergic neurons: What are the implications for future Dravet syndrome therapeutics?Dravet syndromeepilepsyGABAinduced pluripotent stem cellsSCN1AtreatmentFuture Neurology , September 2013, Vol. 8, No. 5, Pages 487-489....
5. Genetics of Bacteria and Viruses1h 21m 6. Chromosomal Variation1h 48m Chromosomal Mutations: Aberrant Euploidy 20m Chromosomal Mutations: Aneuploidy 13m Chromosomal Rearrangements: Overview 8m Chromosomal Rearrangements: Deletions 7m Chromosomal Rearrangements: Duplications ...
1996). A putative truncated protein may retain its ability to bind to 5-methyl CpG. However, since the nuclear-localization signal (NLS) resides within the TRD (Lewis et al. 1992), the truncated protein of 167 amino acids, lacking the NLS, may remain largely in the cytoplasm. Indeed, ...
The study in [16] suggests that, in some cases, single lethal mutations may have the same effect as the accumulation of deleterious ones. However, most studies on P. esculentus fitness, suggest that when in a heterozygous state the effect of deleterious mutation is not significant. Due to ...
What is claimed is: 1. A method of screening an individual for increased risk of low folate status, said method comprising detecting a mutation in a human glutamate carboxypepidase II (GCPII) gene in a biological sample from said individual, wherein detection of the mutation is indicative of...