Are the mutations that cause Huntington's disease present in the DNA, RNA, or both? Explain. In Sickle Cell Anemia and Huntington's Disease, are mutations the result of a mistake in DNA replication or transcription? Explain. Why are there someti...
In this Review, the authors discuss the clinical features of patients with sporadic pituitary adenomas that are associated withAIP or MEN1mutations, and discuss the molecular mechanisms potentially involved in pituitary adenoma tumorigenesis. They also d
Although virtually all mutations that result in osteogenesis imperfecta (OI) affect the genes that encode the chains of type I procollagen, the effects of mutations in the COL1A2 gene have received less attention than those in the COL1A1 gene. We have characterized mutations in 4 families that...
Unfortunately, our dataset does not allow us to assess if the observed mortality rates are the result of shifts in treatment regimes or admission procedures during the sampling window. We then tested if R203K/G204R SNPs were associated with higher viral copy numbers as indicated by the cycle ...
This paper led to assertions that certain forms of cancer are mainly the result of "bad luck", and suggested that these types would be relatively resistant to prevention efforts. The question of random mutations and "bad luck" on cancer brought the question of prominence of environmental (...
Mutations in the PTPN11 gene are associated with various developmental disorders, hematologic malignancies, and solid tumors, playing distinct biological roles in different mechanisms of cancer development [12,13]. Through the PI3K/AKT/GSK3β signaling pathway, PTPN11 has been shown to promote the pro...
Chloroplasts have their own genomes, independent from nuclear genomes, that play vital roles in growth, which is a major targeted trait for genetic improvement in Populus. Angiosperm chloroplast genomes are maternally inherited, but the chloroplast’ var
Over the past few weeks, scientists uncovered two new strains of the Covid-19 virus, the “British” mutation and the “South African” one, are there others out there? “Yes, they are definitely not the only ones. Viruses are constantly changing, each one at its own pace. Both of tho...
transcription. Other NSPs are almost considered in the host cell and immune suppression. Structural proteins of the 3′-end are involved in viral interaction with the host cell angiotensin-converting enzyme 2 (ACE2) receptor, membrane fusion and entry of the virus into the host cells [63,87,...
"Tumors are extremely metabolically active," he said. "Tumors soak up an enormous amount of energy, which is why cancer patients are often exhausted. We could potentially think about ways to target the metabolism of cancer cells. Maybe by slowing their metabolic rate, we could stop the oncogen...