According to the statistical power calculation, 47 500 livebirths are needed to detect a doubling of mutation rate with probabilities of type I and II errors of 0.05 level. In Hungary the average number of yearly births was 135 548 in the study period. 展开 ...
Association between prevalence of pyrimethamine resistance and double mutation in pfdhfr gene in West Bengal, India. Asian Pacific Journal of Tropical Disease 2, 31-35.Das S, Chakraborty SP, Tripathy S, Hati AK, Roy S. Association between prevalence of pyrimethamine resistance and double mutation ...
compared mutation calls between WGS and WES, observing that ~3% of coding variants with high quality were only detected in WGS, and WGS also had a more uniform distribution of coverage depth, genotype quality, and minor read ratio13. Furthermore, due to the relatively high error rate per ...
The type and genomic context of cancer mutations depend on their causes. These causes have been characterized using signatures that represent mutation types that co-occur in the same tumours. However, it remains unclear how mutation processes change during cancer evolution due to the lack of reliabl...
Mutation rate profiles were created independently for somatic substitutions (SNV), indels, somatic copy-number alterations (CNA) and other structural variations (SV). Note that the vast majority of variants, e.g., at least 99% of the SNVs in nearly all samples, used for this analysis are ...
This indicates the involvement of KRAS mutations in the early event of human pancreatic cancer. Similarly, in lung adenocarcinoma, the early lesion detected a mutation of KRAS [33]. Marabese et al., in their study on non-small cell lung carcinoma (NSCLC), detected the highest mutation rate ...