The mutation rate at any specific position in the human genome depends on sequence context. Here, the authors develop a method for predicting mutation rates of point mutations and indels based on sequence context; the results can be used to find genes where de novo mutations cause disease and ...
nonetheless, the mutation rate is not uniform. In some part this is because transposable elements (TEs) have high mutation rates and TEs are rare in gene bodies. InArabidopsis, cytosine methylation-mediated TE suppression16should lead to C instability...
With some differences, mutational signatures in other species resembled those described in humans8, although the relative contribution of each signature varied across species. Notably, the somatic mutation rate per year varied greatly across species and exhibited a strong inverse relationship with species...
we hypothesized that genetic susceptibility to earlier ovarian ageing would be associated with a higher de novo mutation (DNM) rate in offspring. To test this, we analysed
So until large-scale DNA sequencing became practical, measuring the rate at which novel mutations accumulate in a genome was a daunting ... ALEXEY KONDRASHOV - 《Nature》 被引量: 25发表: 2012年 On the Relationship between Mutation Rates and Growth Rates in a Changing Environment - Science...
The rate at which mutations occur in nature is itself under natural selection. While a general reduction of mutation rates is advantageous for species inhabiting constant environments, higher mutation rates can be advantageous for those inhabiting fluctuating environments that impose on-going directional ...
In subject area: Medicine and Dentistry The mutation rate of a virus has been described as the probability that during a single replication of the virus genome a particular nucleotide position is altered. From: Genetics and Evolution of Infectious Disease, 2011 ...
Genomic evolutionary rates are decomposed to identify the dominant lineages and genes driving rate variation across the phylogeny of birds. David A. Duchêne Al-Aabid Chowdhury Simon Y. W. Ho ResearchOpen Access19 Mar 2025Nature P: 1-9
little is known about the evolutionary rate and adaptive potential of shark populations, a fact that has come into sharper focus with the emergence of the dual ecological pressures of overfishing and habitat loss. Specific drivers of overfishing in shark populations are particularly impacting. Firstly...
CHARLESWORTH,MORGAN,MT - 《Nature》 被引量: 0发表: 1990年 Genetic loads and estimates of mutation rates in highly inbred populations ESTIMATES of the rate of mutation to mildly deleterious alleles are fundamental to the testing of theories of the maintenance of sexual reproduction1 and r... B...