The complete genome of an increasing number of animals and plants is known. This knowledge has had an enormous impact in different areas of biology. The completion of theHuman GenomeProject has provided a more functional view of the genetic material, which has an obvious translation into clinics...
Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications p pFLT3 is a type III receptor tyrosine kinase. Mutations of FLT3 comprise one of the most frequently identified types of genetic alterations in acute myel... S Takahashi - 《...
Beyond substitutions and indels, crypts from the eight species with chromosome-level genome assemblies were inspected for large-scale copy number changes (at least 1 Mb) (Methods). Studies in humans have found that large-scale copy number changes are relatively rare in normal tissues, including ...
In subject area:Biochemistry, Genetics and Molecular Biology Mutation accumulation is a process in which deleterious alleles with age-specific effects reach non-zero equilibrium frequencies determined by mutation–selection balance. From:Trends in Ecology & Evolution,2006 ...
Heupel, M. R., Whittier, J. M. & Bennett, M. B. Plasma steroid hormone profiles and reproductive biology of the epaulette shark, Hemiscyllium ocellatum.J. Exp. Zool.284, 586–594 (1999). ArticleCASPubMedGoogle Scholar Rhie, A. et al. Towards complete and error-free genome assemblies...
Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant pathways, cell cycle, neuronal protection, a
We show here that the mating-type phenotype associated with sum1-1 results from a dramatic reduction in the steady-state level of HML and HMR gene transcripts. At the same time, the sum1-1 mutation has no significant effect on the level of each of the four MAR/SIR mRNAs. 展开 ...
(Fig.4a, b). In contrast to the ASD-related mPOGZ mutants, control mPOGZ mutants, including the R1005H-, F1051L- and H1084R-POGZ mutants, rescued thePogz-knockdown-mediated migration defect to virtually the same level as WT-mPOGZ expression at E18.5 (Fig.4c, d). Thus, the ASD-...
[40] as a result of theIDH1mutation. Interestingly, the percentage of the predicted MGPs associated with lipid metabolism was remarkably different between two sarcomas, SoftTissue-Liposarc and SoftTissue-Leiomyo, and this different metabolic composition appeared to be consistent with their biology [...
Discovery of such a mutation supplements current knowledge regarding the role of the SLC4A2 anion exchanger in the bone resorption process and furthers understanding of osteoclast biology. Additionally, the development of a DNA-based assay that can serve as a molecular diagnostic test for ...