The complete genome of an increasing number of animals and plants is known. This knowledge has had an enormous impact in different areas of biology. The completion of theHuman GenomeProject has provided a more functional view of the genetic material, which has an obvious translation into clinics...
In subject area:Biochemistry, Genetics and Molecular Biology Mutation accumulation is a process in which deleterious alleles with age-specific effects reach non-zero equilibrium frequencies determined by mutation–selection balance. From:Trends in Ecology & Evolution,2006 ...
Lack of progress in improving treatment outcomes has been attributed to limited knowledge of the underlying biology, although large-scale genomic studies have begun to provide insights. We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls), and through ...
Discovery of such a mutation supplements current knowledge regarding the role of the SLC4A2 anion exchanger in the bone resorption process and furthers understanding of osteoclast biology. Additionally, the development of a DNA-based assay that can serve as a molecular diagnostic test for ...
Heupel, M. R., Whittier, J. M. & Bennett, M. B. Plasma steroid hormone profiles and reproductive biology of the epaulette shark, Hemiscyllium ocellatum.J. Exp. Zool.284, 586–594 (1999). ArticleCASPubMedGoogle Scholar Rhie, A. et al. Towards complete and error-free genome assemblies...
phylogenetic relationships (Extended Data Fig.13a, b, Methods); and bootstrapping analyses at the level of individuals or species (Extended Data Fig.13c, Methods). Mutational processes and lifespan To investigate whether a single biological process could drive the association between somatic mutation...
During the entire ontogenesis of SAMP1 mice, the frequency of circular spermatids with micronuclei corresponded to the level observed upon induced mutagenesis.doi:10.1023/A:1026650519457S. T. ZakhidovO. F. GordeevaT. L. MarshakKluwer Academic Publishers-Plenum PublishersBiology Bulletin of the ...
C. López-Otín (Dept. of Biochemistry and Molecular Biology, University of Oviedo) and Dr. C. Suarez-Nieto (Instituto Universitario de Oncología del Principado de Asturias IUOPA) for support and advice, Dr. M.V. Alvarez (Laboratory of Genetics, Hospital Universitario Central de Asturias) for...
However, the level of CEA continued to rise (Fig. 1). To establish an effective treatment, next-generation sequencing (NGS) was used for DNA sequencing analysis. The result showed that the patient had a HER2 p.Asp769Tyr mutation (c.2305G>T) (Fig. 4). Simultaneously, he also had ...
We also observe slightly greater frequency of mutations just below the level of AF=1. This may suggest a slightly higher per-base read error rate or possibly alignment errors. The OF data in panels C and D is distinct from the TST170 data primarily in that many fewer bases are covered. ...