the steps to determine the MATH value can be summarized as follows: (1) calculating the mutant-allele fraction (MAF) for each locus as the ratio of mutant reads to total reads; (2) obtaining the absolute differences of each MAF from the median MAF value, multiplying the median of these a...
MAFmetastatic colorectal cancerprognostic biomarkerRAS analysisDespite major advances in the treatment of metastatic colorectal cancer (mCRC), the survival rate remains very poor. This study aims at exploring the prognostic value of RAS‐mutant allele fraction (MAF) in plasma in mCRC. Forty‐seven ...
the steps to determine the MATH value can be summarized as follows: (1) calculating the mutant-allele fraction (MAF) for each locus as the ratio of mutant reads to total reads; (2) obtaining the absolute differences of each MAF from the median MAF value, multiplying the median of these a...
the steps to determine the MATH value can be summarized as follows: (1) calculating the mutant-allele fraction (MAF) for each locus as the ratio of mutant reads to total reads; (2) obtaining the absolute differences of each MAF from the median MAF value, multiplying the median of these a...
3541#Background:Measurement of plasma mutant allele fraction (MAF) in patients with cancer provides prognostic information, but this approach typically rel... A Leal,IV' Erve,K Lumbard,... - 《Journal of Clinical Oncology》 被引量: 0发表: 2022年 1266P Genetic profiling of cell-free DNA fr...
a Fraction of the genome altered across pan-cancer (n = 958, left panel) and breast cancer cell lines (n = 53, right panel) from the Cancer Cell Line Encyclopedia, with (red) and without (black) TP53 alterations (mutation or deletion); including the nontransformed MCF10A cell ...
Élez E, Ros J, Martini G et al (2021) LBA-3 Integrated analysis of cell-free DNA (cfDNA) BRAF mutant allele fraction (MAF) and whole exome sequencing in BRAFV600E metastatic colorectal cancer (mCRC) treated with BRAF-antiEGFR +/- MEK inhibitors. Ann Oncol 32:S226–S227 Article Goo...
We and others described RAS mutant allele fraction in plasma (plMAF) as an independent prognostic marker in metastatic CRC (mCRC). Here, we explored the predictive value of plMAF in RAS mutant pts treated in first line with chemotherapy +/- bevacizumab (bev). Methods A multicentric ...
NGS can quantitate the proportion of reads for a given mutation, also known as mutant allele frequency (MAF), which represents the percentage of tumor cells that harbor a specific mutation in a neoplastic tissue. The sensitivity of NGS is higher than that observed with Sanger sequencing (2–10...