11.4.7Specialised protein structures: mussel adhesives and genetic engineering This is a very interesting and active research field. The difference, in terms of adhesion principles, between commonmussel adhesiveprotein and the mammalian proteins considered above, is that this protein appears to for...
This temperature-responsive controlled adhesion hydrogel is mainly composed of two parts: a mussel-inspired guest adhesive copolymer and a heat-sensitive host copolymer.As guest copolymers, they synthesized DOPA, guest adamantane (AD) and methoxyethyl acrylate (MEA) monomers into pDOPA-AD-MEA. The ...
An acrylamide-type copolymer containing catechol, amino, and hydroxyl groups was synthesized as a mimetic of the natural mussel adhesive protein (MAP). The obtained copolymer in a phosphate buffer solution (pH = 8.0) formed a hydrogel within 2 h under air, whereas gelation did not proceed ...
which enable these organisms to bind tightly to various surfaces under water. One of the key structure component of mussel adhesive protein (MAP) is the presence of a catecholic amino
First, PVA-DOPA polymers were synthesized by modifying PVA with the mussel adhesive protein DOPA. The formation of PVA-DOPA1-6 (according to the content of DOPA added, refer to the Materials section) was confirmed by Fourier transform infrared (FTIR), ultraviolet-visible (UV-vis), and 1H-nu...
Mfp-3slow, a matrix protein of the adhesive plaque, can also form coacervate driven by hydrophobic interactions8. Mfp-5 is the first secreted protein to initiate the wet adhesion of mussels during the plaque formation22,23. It has the highest Dopa content (~30%) and the highest adhesion ...
Engineering a mussel-inspired hemostatic sealant with a strong tissue anchor as a first-aid tissue adhesiveMaterials Today Chemistry (IF 6.7)Atousa Ashrafi, Elham Khadem, Mahshid Kharaziha Pub Date: 2023-12-29 Harnessing Macromolecular Chemistry to Design Hydrogel Micro- and Macro-EnvironmentsMacromole...
been used a lot as a nonhydrogel form tissue adhesive, adheres strongly to tissue surfaces after injection but is too cytotoxic for cell delivery and too rigid to accommodate soft tissue movement. 19 Fibrin glues (e.g., TISSEEL from Baxter AG), as protein hydrogels, are more cytocompatible ...
Fmoc-based solid-phase peptide synthesis (SPPS) [26] is a classical method for preparation of peptide drugs or protein epitopes. The simplest idea for mussel adhesive peptide mimicking might be the chemical introduction of catechol groups onto the pre-synthesized peptides. For example, Tang et al...
A stable and efficient mussel-inspired nanozyme was developed by chelating ultrasmall Ag nanoparticles with tannic acid, and was employed to trigger hydrogel self-setting without external stimuli, and endow it with antibacterial, conductive, and adhesive properties in a facile manner for bioelectronics....