Valentine BA, et al. Canine X-linked muscular dystrophy as an animal model of Duchenne muscular dystrophy: a review. Am J Med Genet 1992;42:352-356. Wetterman CA, et al. Hypertrophic muscular dystrophy in a young dog. J Am Vet Med Assoc 2000;216:878-881. Winand NJ...
Spinal muscular atrophy (SMA), an autosomal recessive neuromuscular disorder characterized by loss of alpha motor neurons, causes severe muscle weakness and atrophy presenting at or shortly after birth.1,2SMA is the leading genetic cause of infant death after cystic fibrosis.3The incidence of SMA i...
CD11b/LIF mdx transgenic mice were produced by crossing CD11b/LIF hemizygous males with mdx females to generate CD11b/LIF hemizygous, transgenic mice that were also dystrophin-deficient (CD11b/LIF mdx). Dystrophin-deficient status was verified by ARMS PCR screening65 and presence of the hCD11b...
A second post-hoc meta-analysis of a Phase IIb study and the ACT-DMD trial evaluated the effi- cacy of deflazacort versus prednisone/prednisolone in terms of prolonging the ability to perform the 6-minute walk test and timed function tests in the placebo arms of two ataluren...
Skeletal muscle weakness results in significant physical limitations, including progressive loss of facial muscles that can cause an inability to smile or communicate, difficulty using arms for activities of daily living and difficulty getting out of bed, with many patients ultimately becoming dependent ...
while the m. extensor hallucis longus and brevis are active in the swing phase. It should be noted that the arms of the force of both muscles in relation to the axis of rotation of the upper, lower, and Chopart ankle joint as well as the axis of the first toe unit are almost identic...
It should be noted that the arms of the force of both muscles in relation to the axis of rotation of the upper, lower, and Chopart ankle joint as well as the axis of the first toe unit are almost identical, but located on both sides of the above-mentioned axis. Besides this, the ...
Blood pressure was verified indirectly using an aneroid sphygmomanometer (Tycos) situated on the patients’ left arms and a stethoscope over the median area of the antecubital fossa. Respiratory rate (RF) was measured by counting respiratory incursions during a one-minute period. 2.5. Heart ...