The awareness as well as the relevance of sarcopenia has increased over the last years. Since January 2018, sarcopenia has been included in the German version of the International Classification of Diseases (ICD-10-GM) and...
Owing to the importance of age-related muscle weakness for overall health of the elderly, the World Health Organization has established ICD-10-CM disease code for sarcopenia4. Sarcopenia can be triggered by a variety of conditions, including hormonal imbalances, loss of motor neurons, inflammation,...
Excessive force against the muscle from pushing by other athletes in contact sports or excessive load on the muscle during training may cause inflammation of the insertion tendon on the humerus. Thisinjurymay produce pain andweaknessin the shoulder, and difficulty raising the arm. ...
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nat. Commun. 12, 654 (2021). Article CAS PubMed PubMed Central Google Scholar Viatte, S. et al. Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and ...
In DM2 (or proximal myotonic myopathy [PROMM]), the genetic defect consists of a CCTG repeat expansion (75 to 11,000 repeats) in intron 1 of the CNBP/ZNF9 gene. DM2 patients complain of skeletal muscle pain and weakness, myotonia (from 60% [166] to 85% [167]), hypogonadism (...
(lower than 0.8 g/kg/body weight) as well as lack of physical activity. Muscle weakness has also been associated with a higher risk of osteoporosis independently of physical activity.5, 6 In keeping with this finding,...
Moreover, the possibility of a relationship between pneumonia-induced death and respiratory muscle weakness was suggested [20]. In aged males, strong leg force showed a potential to improve the relationship between impaired % FVC and higher mortality [9]. Currently, the disease that causes the ...
Myotonic dystrophy (DM) is the best-known splicing-associated neuromuscular disease which is characterized by muscle weakness, cardiac conduction abnormalities, and cardiomyopathy [35–37]. Cardiac abnormalities are common in more than 80% of the DM patients and related to 30% of the mortality in ...
These mice develop age-dependent desmin-positive protein aggregation pathology, skeletal muscle weakness, dilated cardiomyopathy, as well as cardiac arrhythmias and conduction defects. For the first time, we report the expression level and subcellular distribution of mutant versus wild-type desmin in our...
A significant consideration in assessing a patient with muscle weakness is the presence or absence of intellectual disability, thus narrowing the differential diagnostic approach in any child with an as yet undiagnosed muscle disease. Intellectual disability in neuromuscular diseases is often associated ...