Atrophy and loss of muscle fibers are accompanied by structural remodeling of motor units. Muscles of older people are weaker and less powerful than those of the young, even after correction for muscle size. A reduced oxidative capacity can increase fatigability during dynamic movements, but slower...
potentially leading to more ICU-associated deaths [9]. Taken together, these data clearly suggest different responses to atrophic stimuli between males and females and highlight the need for further research investigating mechanisms for muscle wasting across...
Skeletal muscle is derived from the mesoderm. Myogenesis involves a continuous and dynamic series of biosynthetic and restructuring events that result in the molding of fetal tissue, ultimately leading to adult muscle with its distinct metabolic, structu
bnlRNAi) attenuated muscle wasting in animals raised on an HSD (Fig.2g, h, kand Supplementary Fig.3f, g, q), indicating that tumour-derived Bnl is required for muscle wasting. Tumour-derived factors recently implicated in cachexia-like organ wasting include ImpL2 and Pvf19,10,11. However,...
Muscle wasting in these conditions is mainly caused by increased proteolysis, at least in part regulated by nuclear factor-κB. Despite recent progress in the understanding of mediators and mechanisms involved in muscle wasting, effective and universally accepted treatments by which muscle atrophy can ...
Our results suggest that the ubiquitin-proteasome pathway is an appropriate therapeutic target to inhibit muscle wasting and emphasizes the role of allopurinol as a non-hormonal intervention to treat disuse muscle atrophy.doi:10.1038/s41598-018-21552-1Beatriz Ferrando...
Muscle wasting in collagen-induced arthritis and disuse atrophy.###HMB attenuates muscle loss during sustained energy deficit induced by calorie restriction and endurance exercise.###Functional conservation between mammalian MGRN1 and plant LOG2 ubiquitin ligases.###R-loop formation at Snord116 mediates...
Muscle wasting in chronic alcoholics: comparative histochemical and biochemical studies. J Neurol Neurosurg Psychiatry 1983; 46: 248-54.Langohr, H.D., Wietho¨ lter, H., Peiffer, J., 1983. Muscle wasting in chronic alcoholics: comparative histochemical and biochemical studies. J. Neurol. Neuro...
Muscle atrophy (cachexia) is a muscle wasting syndrome associated with several pathological conditions in humans such as congestive heart failure, diabetes, AIDS, cancer and renal failure, and the presence of cachexia worsens outcome. Many of the conditions associated with cachexia are accompanied by ...
With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasom