though the process of losing muscle begins decades before that. In addition to the biological changes that are part of the aging process, older adults are likely to have additional risk factors, such as inactivity, a poor diet, and chronic disease, which contribute to loss of muscle and stren...
Strength and muscle quality in a well-functioning cohort of older adults: the Health, Aging and Body Composition Study. OBJECTIVES: To determine whether lower lean mass and higher fat mass have independent effects on the loss of strength and muscle quality in older adults an... AB Newman,CL ...
With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasom
Skeletal muscle aging is characterized by the loss of both muscle mass and strength, often leading to sarcopenia4. This is a major contributory factor to falls and fractures in older adults, the second-leading cause of injury and deaths5. During aging, there is a selective decrease in both t...
An association between oxidative stress and muscle atrophy and weakness in vivo is supported by elevated oxidative damage and accelerated loss of muscle mass and force with aging in CuZn-superoxide dismutase-deficient (Sod1(-/-)) mice. The purpose was to determine the basis for low specific forc...
Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic
Loss of muscle mass and related function is a feature typically exhibited by people with chronic diseases as well as during aging [16]. Age-related musculoskeletal conditions, which includes fragility fractures, low muscular mass and strength, and frailty, are associated with chronic inflammation [17...
10. Aging-related Elevation in Phd2 is Responsible for the Loss of Muscle Adaptation to Exercisedoi:10.1097/01.GOX.0000937636.43715.7aCharles HwangHarvard University MGH/BWH, Boston, MA, USAYori EndoBrigham and Women’s Hospital, Boston, MA, USA.Yuteng Zhang...
One of the distinctive features of aging is the progressive loss of muscle mass and physical function, collectively known as sarcopenia3. The loss of skeletal muscle mass and tissue function has been related to mobility impairments4, such as difficulties walking short distances or standing up from...
Moreover, during physical inactivity, aging and some metabolic disorders, skeletal muscle losses in mass due to atrophy of individual myofibers3. Among different cellular, molecular and structural components, CSA quantification of myofibers in microscopic images is widely used since it reflects the ...