Muscle atrophy and bone loss after 90 days’ bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study. Bone. 2005; 36 :1019–1029. doi: 10.1016/j.bone.2004.11.014. [ Cross Ref ]Rittweger J, Frost HM, Schiessl H, Ohshima H, Alkner B, ...
functional activity is significantly diminished in SBMA muscle, and overexpression of constitutively active MEF2 rescues atrophy. Similar changes are observed in skeletal muscle from R6/2 mice, a transgenic mouse model of HD, suggesting that functional impairment of MEF2 results from the expanded polyQ ...
Increased secretion of complement component 1q with aging results in muscle fibrosis and atrophy, while resistance training can reduce muscle fibrosis and atrophy via downregulating the C1q-induced Wnt signaling in aging mice [81]. In addition, radiothione prevents radiation-induced muscle fibrosis by...
This study would benefit patients who suffered from persistent quadriceps weakness and atrophy after ACLR, thus improving the post-operative outcome. This study aims to conduct a double-blinded, randomized controlled trial to examine the therapeutic effects of vitamin D supplements on improving quadriceps...
Denervation and hence loss of muscle contraction has an immediate effect on gene expression in myonuclei and results after a few days in exuberant muscle atrophy. It indirectly also affects satellite cells and many other muscle-resident mononuclear cells. As somatic gene deletion may affect innervatio...
The results of repair of massive tears of the rotator cuff Massive tears of the tendons of the rotator cuff cause atrophy and fatty degeneration of the rotator cuff muscles and painful loss of function of the shoul... C Gerber,B Fuchs,J Hodler - 《Journal of Bone & Joint Surgery American...
Glucocorticoids are able to reduce chronic inflammation, but they directly stimulate muscle fiber atrophy and impair MuSC functioning19,20,21. On the other hand, RvD2 represents a versatile therapeutic option that targets many of the harmful effects caused by the lack of dystrophin. The findings ...
Depending on the test results, your doctor may refer you to a specialist for further evaluation. Muscle Atrophy Treatment Treatment for muscle atrophy depends on the type and may include: Physical therapy Regular exercise Dietary changes or supplements Surgery (in some cases of contracture deformit...
Mild denervation, where limited numbers of motor units are involved, results in scattered single or small contiguous groups of atrophic fibers. These become compressed by adjacent normal innervated fibers into angular shapes, the lesion being referred to as angular atrophy (see Fig. 3-11A, B). ...
Age-related muscle atrophy results in mitochondrial fission which in turn promotes the activation of proteolytic pathways (Cartee et al., 2016). Consistently, fission inhibition prevents muscle loss in atrophying conditions (Romanello and Sandri, 2015). In COMB group, expression of regulators of ...