mTOR in Muscle Atrophy Muscle atrophyis defined as a decrease in the mass of the muscle and can be a partial or complete wasting away of a muscle[1]. Muscle atrophy is caused by several common diseases, such as cancer, diabetes, and renal failure; severe burns; starvation; and disuse of...
A 43-kDa protein related to c-Erb A al is located in the mitochondrial matrix of rat liver. J Biol Chem 1995; 270: 1634716354. Google Scholar Almon RR, Dubois DC. Fiber-type discrimination in disuse and glucocorticoid-induced atrophy. Med Sci Sports Exerc 1990; 22: 304–311. PubMed ...
(2007). Muscle Atrophy as a Consequence of Rotator Cuff Tears: Should We Compare the Muscles of the Rotator Cuff with Those of the Deltoid? Heidelberg: Springer Berlin.Ashry R,Schweitzer ME,Cunningham P,et al.Muscle atrophy as a consequence of rotator cuff tears: should we compare the ...
Upon OMM fusion, the optic atrophy protein 1 (OPA1), a dynamin-like GTPase located in the IMM, is required for IMM fusion [72]. OPA1 deletion leads to mitochondrial fragmentation, whereas OPA1 overexpression induces mitochondrial elongation [73]. Post-translational modifications control mitochondria...
54 This study has shown diffuse atrophy of gastrocnemius muscle fibers and increased variation in fiber size, but no clear evidence for denervation. The terminal innervation ratio is significantly increased not only in wobbler mice, but also in dystrophic mice. Muscle histometry has yet to be ...
Skeletal muscle is also an endocrine organ that secretes myokines that have an effect on the whole-body organs [1,2,3]. Skeletal muscle atrophy is closely associated with some conditions such as sedentary, physical inactivity and cachexia [4, 5]. Skeletal muscle atrophy can seriously impact ...
Lunar gravity prevents skeletal muscle atrophy but not myofiber type shift in mice Article Open access 21 April 2023 Introduction As the field of space exploration progresses towards missions to Mars, the development of permanent lunar bases, and the privatization of space travel, there is a conco...
The E3 ligases so far described are activated during atrophy, but none of these cause atrophy when overexpressed in normal muscles19. An exception is the muscle-specific ubiquitin ligase, SOCS box protein 2 (Asb2b)22, which was identified to be repressed by Follistatin and to be critical for...
disuse, aging, and diabetes. The adverse consequences of muscle atrophy are not limited to a decrease in muscle function, but can profoundly affect overall quality of life of patients (Fearonet al., 2011). Cachexia is clinically distinct from anorexia and is defined as a complex metabolic syndr...
function with ageing, with type II fibres being more susceptible than type I fibres to atrophy (Larsson et al.1978; Lexell et al.1988; Nilwik et al.2013). There is also evidence for increases in the ratio of type I to type II fibres in humans (Larsson et al.1978; Larsson1995; Ander...