while exhibiting vastly different size and regenerative potential. Healthy skeletal muscle harbors a robust regenerative response that becomes inadequate after large muscle loss or in degenerative pathologies and aging. In contrast, the mammalian heart loses its...
Article Open access 21 March 2024 Introduction Mitochondria play a key role in cellular homoeostasis and the proper regulation of mitochondrial transport ensures their position at sites where energy demands or oxygen supplies are the greatest [1]. Consequently, mitochondria can redistribute in response ...
Cerebral palsy (CP) is caused by a static lesion to the brain occurring in utero or up to the first 2 years of life; it often manifests as musculoskeletal impairments and movement disorders including spasticity and contractures. Variable manifestation of the pathology across individuals, coupled...
poop out, conk out, peter out, run down, run out - use up all one's strength and energy and stop working; "At the end of the march, I pooped out" retire, withdraw - lose interest; "he retired from life when his wife died" 2. fatigue - exhaust or get tired through overuse or...
Survey contents and procedure manuals can be found at https://www.cdc.gov/nchs/nhanes/index.htm (accessed March 2021). This survey represents non-institutionalized community-dwelling residents in the United States and, as such, uses multistage, stratified, complex probability sampling designs and ...
Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical function. However, the underlying molecular processes and how (lack of) physical activity is involved in age-related metabolic decline in muscle function in human
Accordingly, in the present study we sought to determine the relative contribution of muscle strength, lean mass, and an index of lower extremity motor function (performance time on the four square step test, which is discussed more below), in explaining between-participant variance in measures ...
oxidative metabolism↑; muscle strength and performance↑; cramps frequency↓; mtDNA deletion ; mitochondrial ultrastructure . (Pirinen et al., 2020) Individuals with T2DM (57.7 ± 1.1 years old) Acipimox, 250 mg three times daily, 2 weeks Mitochondrial respiration↑; ATP content↑. (...
et al. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev. Cell 17, 662–673 (2009). PubMed PubMed Central Google Scholar Puigserver, P. et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829...
14 As the disease progressed almost every muscle of the body became involved in this non-performance, visually testifying to the patient’s loss of physical autonomy and strength . Finally, many patients were confined to bed, due either to a complete inability to walk, or as a precautionary ...