From a theoretical standpoint, skeletal muscle is a primary driver of the relationship between body composition, bone health, and clinical outcomes, as it is involved in mobility, strength, and balance. However, while muscles play a vital role in human h
two cohorts, the UK Biobank and Helsinki Birth Cohort Study in which gene expression-reducing variants ofSPTLC1andDEGS1are associated with improved and reduced fitness of older individuals, respectively. These findings identify sphingolipid synthesis inhibition as an attractive therapeutic strategy for age...
2. Toward a better understanding of low muscle mass and malnutrition as overlapping conditions 3. Emerging evidence on the pathophysiology of low muscle mass 4. Who is at risk of malnutrition and muscle loss? 5. Identify at-risk patients 6. Can we prevent or revert muscle loss and malnutritio...
However, physical activity programs, tailored to individual factors like age, fitness, and comorbidities, are strongly recommended and should include 150–300 min of moderate or 75–150 min of vigorous exercise weekly, along with muscle-strengthening exercises [240]. Different forms of training, ...
Costill DL, Flynn MG, Kirwan JP, et al. Effects of repeated days of intensified training on muscle glycogen and swimming performance. Med Sci Sports Exerc. 1988;20(3):249–54. Article CAS PubMed Google Scholar Lehmann M, Foster C, Keul J. Overtraining in endurance athletes: a brief re...
“Physical activity” refers to any level of activity above seated rest that results from skeletal muscle activation and leads to movement and an increase in energy expenditure, whereas “exercise” refers to planned, structured, repetitive activity aimed to improve fitness (Caspersen et al., 1985)...
J.P. Kirwan, A. Varastehpour, M. Jing, L. Presley, J. Shao, J.E. Friedman, P.M. Catalano Reversal of insulin resistance postpartum is linked to enhanced skeletal muscle insulin signaling J. Clin. Endocrinol. Metab, 89 (2004), pp. 4678-4684 View in ScopusGoogle Scholar 21 K.M. ...
& Kirwan, J. P. Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle. J. Appl. Physiol. (1985) 117, 239–245 (2014). Article CAS Google Scholar Finkel, T. The metabolic regulation of aging. Nat. ...
Exercise could potentially be a promising intervention strategy for the prevention and treatment of cancer-related cachexia. With the ability to increase FFM, muscle strength and function, cardiovascular fitness and decrease fatigue, ultimately resulting in an increased quality of life, exercise may be ...
Kirwan, R.; Isanejad, M.; Davies, I.G.; Mazidi, M. Genetically Determined Serum 25-Hydroxyvitamin D Is Associated with Total, Trunk, and Arm Fat-Free Mass: A Mendelian Randomization Study. J. Nutr. Health Aging 2022, 26, 46–51. [Google Scholar] [CrossRef] Sha, T.; Li, W.;...