PLURIPOTENT stem cellsCELL populationsSTEM cell researchBONE marrowHEMATOPOIETIC stem cellsSTEM cellsREGENERATIVE medicineThe concept of "stemness" incorporates the molecular mechanisms that regulate the unlimited self-regenerative potential typical of undifferentiated primitive cells. These cells possess the ...
PLURIPOTENT stem cellsDISEASE progressionNEURAL circuitryMOVEMENT disordersPROGRESSIVE supranuclear palsyParkinson's disease (PD) is a progressive neurodegenerative disorder characterized by continuous and selective degeneration or death of dopamine neurons in the midbrain, leading to dysfun...
Francesca Becherucci Paola Romagnani News & Views05 Mar 2018Nature Reviews Nephrology Volume: 14, P: 215-216 CSCs and pluripotent/multipotent stem cells Comments & Opinion28 Sept 2017Laboratory Investigation Volume: 97, P: 1124-1125 Nature.com...
Compared to adult stem cells, they exhibit a significantly higher differentiation potential and are much easier to propagate in vitro. Compared to pluripotent stem cells, they harbor less mutations, are not tumorigenic, and exhibit low immunogenicity. Studies on multipotent fetal stem cells can be in...
The present invention relates to the differentiation of human pluripotent cells, including human pluripotent stems cells to produce a self-renewing multipotent neural crest cell population in a single
Our previous studies described the derivation of an early neural progenitor cells derived from human pluripotent stem cell (hPSC), phenotypically defined as OCT4−/SOX2+/PAX6− 10. These progenitors are generated by 4 days treatment of hPSC with small molecule inhibitors of glycogen synthase kina...
Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) play a pivotal role in maintaining lifelong hematopoiesis. The distinction between stem cells and other progenitors, as well as the assessment of their functions, has long been a central focus in stem cell research. In recent years...
This month's special issue of Laboratory Investigation focuses on cancer stem cells (CSCs) and pluripotent/multipotent stem cells. These two types of stem cells differ in origin but share common biological features such as self-replication and multipotency. The CSC theory states that organ-specific...
Currently, two major types of stem cells are being investigated: multipotent stem cells (adult stem cells) and pluripotent stem cells (ESCs or iPSCs) have been studied as potential cell sources for heart regeneration. Adult stem cells can be isolated from different tissues, such as skeletal musc...
We show that dual inhibition of the glycogen synthase kinase 3β and activin/nodal pathways by small molecules differentiate human pluripotent stem cells (hPSCs) directly into a preneuroepithelial progenitor population we named "caudal neural progenitors" (CNPs). CNPs coexpress caudal neural plate ...