Multiple sclerosis (MS) is a chronic demyelinating autoimmune disease of the central nervous system (CNS) that predominantly affects young adults1,2,3. However, the clinical presentation, onset, and disease course of MS may vary depending on genetic susceptibility and environmental factors, including ...
Hippocampal sclerosis, n (%) No 418 (87.4) 962 (86.7) 1133 (91.1) Yesc 60 (12.6) 147 (13.3) 111 (8.9) Abbreviations: ADGC = Alzheimer's Disease Genetics Consortium; ADRC = Alzheimer's Disease Research Center; ADSP = Alzheimer's Disease Sequencing Project; NFT = neurofibrillary tangle; ...
MS Society using honor to find donors, leaders. (National Multiple Sclerosis Society Michigan Chapter Inc.)Roush, Matt
Over the course of years, she compiled and tested a way to assess what life is like for people with multiple chronic conditions, from glaucoma and heart arrhythmias to multiple sclerosis and a history of knee, hip and spinal disc problems. But it's not as simple as counting the number of...
In addition, a large number of immune-mediated inflammatory disease genes are over-represented in the blood and artery aging gene signatures, including Crohn's disease, inflammatory bowel disease, multi- ple sclerosis, rheumatoid arthritis, and ulcerative colitis. Chronic low-grade systemic inflammation...
Journal of Neuroinflammation https://doi.org/10.1186/s12974-019-1622-1 (2019) 16:215 RESEARCH Open Access Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis Barakat Alrashdi1,2, Bassel Dawod3, Andrea Schampel4, Sabine Tacke4, Stefanie Kuerten4, Jean ...
This seems to be the main reason autoimmune disorders tend to coincide, according to Berkovich, who has studied multiple sclerosis (MS) extensively. “A second scenario is that when we use immunomodulatory drugs to treat MS, the initial landscape of the imm...
Additionally, lipid-rich diets have been shown to increase the proliferation of mesangial cells in the kidney and contribute to the development of glomerulo- sclerosis by the accumulation of lipid deposits and foam cells in mesangial areas (Song et al, 2000). The presence of ABCA1 in murine ...
hFOB cells were treated in two different 96-well plates, as previously described, DCF-DA was added at the end of treatment and incubated at 37 °C for 20 min, and DCF-DA fluorescence was monitored through live-cell imaging using the IncuCyte imaging system (Essen BioScience, Arbor Michigan...
multiple sclerosis (MS);genetic wide association study (GWAS);single nucleotide polymorphisms (SNPs);natural killer cells;human leukocyte antigen (HLA) complex;natural killer gene complex (NKC);leukocyte receptor complex (LRC);multi-variate regression analysis;elastic net;gene–gene interaction...