Figure 4.Demyelinated plaque occurring in the brain of a patient with multiple sclerosis. Tissue section staining with Luxol fast blue visualizes myelinated areas (dark) and regions devoid of myelin (light). Many factors have been linked etiologically with MS. CD4+and CD8+lymphocytes have bot...
Our incomplete understanding of the causes and pathways involved in the onset and progression of multiple sclerosis (MS) limits our ability to effectively treat this complex neurological disease. Recent studies explore the role of immune cells at differe
Quantification of ms lesions Mri: contributions to understanding ms Conclusions Article Information References A slice of magnetic resonance imaging scan of a patient with multiple sclerosis showing characteristic periventricular lesions with increased signal on T2-weighted (A) and proton-density (B) ...
This study evaluates changes in the prognosis of pediatric-onset multiple sclerosis over time in association with changes in therapeutic and managing
Multiple sclerosis (MS) is the most common chronic inflammatory, demyelinating and neurodegenerative disease of the central nervous system in young adults. This disorder is a heterogeneous, multifactorial, immune-mediated disease that is influenced by both genetic and environmental factors. In most patie...
Objective To investigate whether diffusion-tensor magnetic resonance imaging and whole brain N-acetylaspartate (WBNAA) proton magnetic resonance spectroscopy can provide complementary pieces of information to achieve a better understanding of the factors associated with disability in multiple sclerosis (MS)....
In the management of patients with multiple sclerosis (MS), providers are all faced with the highly formidable challenge of ascertaining whether, and to
Aspirin is widely used to lessen the risks of cardiovascular events. Some studies suggest that patients with multiple sclerosis have an increased risk for some cardiovascular events, for example, venous thromboembolism and perhaps ischemic strokes, raisi
Article Information Conflict of Interest Disclosures:None reported. Source:McGinley MP, Goldschmidt CH, Rae-Grant AD. Diagnosis and treatment of multiple sclerosis: a review.JAMA. 2021;325(8):765-779. See More About Patient InformationMultiple SclerosisJAMA Patient Information...
ObjectiveTo reassess, in a cohort of patients with early-onset multiple sclerosis, the long-term evolution of cognitive deficits, their relationship to