Taking into account these facts, we aimed to investigate the possibility of NET-related changes in glycan composition on circulating IgG molecules and IgG–IgM immune complexes in multiple sclerosis (MS). This autoimmune disorder still has no reliable detection markers or established ways of treatment...
Stimulated by the successful introduction of interferon-β as treatment for relapsing-remitting multiple sclerosis (MS) and based on an improved knowledge of the immunopathology of MS, a vast array of treatment options is currently under investigation for disease course modification. These are targeting...
CCSVI as a cause of multiple sclerosis has been receiving a lot of press and interest. Does the evidence support angioplasty for CCSVI as an effective treatment for MS? Response from Randall T. Schapiro, MD Clinical Professor of Neurology, University of Minnesota, Minneapolis, Minnesota If we ...
We noticed that a hypothesis based on the effect of geomagnetic disturbances (GMD) has the ability to explain special features of multiple sclerosis (MS). Areas around geomagnetic 60 degree latitude (GM60L) experience the greatest amount of GMD. The easiest way to evaluate our hypothesis was to...
Recent research revealed that various pathological conditions, such as cancer, obesity, diabetes, cardiovascular diseases, alcohol injury, and neurodegenerative disorders such as Huntington's disease (HD), Alzheimer's disease (AD), amyotrophic lateral sclerosis and Parkinson's disease (PD) are ...
In the following sections, we will provide insight into the potential role of meningeal lymphatic system in two major neurological disorders, Alzheimer’s disease (AD) and multiple sclerosis (MS), and possible implications to other neurological disorders will also be discussed. Amyloidosis in the ...
A cure formultiple sclerosisfrom this therapy is not around the corner, if at all, yet the media decided to exploit the MS community with their headlines. This caused quite a stir for hopeful patients crossing their fingers. Shame on the media for putting aside journalistic integrity in favor...
Brockington A, Heath PR, Holden H, Kasher P, Bender FL, Claes F, Lambrechts D, Sendtner M, Carmeliet P, Shaw PJ: Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis. BMC Gen...
Keywords: wearables;sensors;ontologies;symbolic reasoning;knowledge graphs;ehealth;multiple sclerosis
This paper is concerned with variational methods applied to functionals of the calculus of variations in a multi-dimensional case. We prove the existence of multiple critical points for a symmetric functional whose principal part is not subjected to any upper growth condition. For this purpose, nons...