Increasing age and disease progression negatively impact remyelination in Multiple Sclerosis. Here authors show that genetically edited human oligodendrocyte precursor cells may help overcome remyelination inhibitors and improve remyelination after transplantation into mouse brain. ...
Multiple sclerosis (MS) is the most common chronic inflammatory, demyelinating and neurodegenerative disease of the central nervous system in young adults. This disorder is a heterogeneous, multifactorial, immune-mediated disease that is influenced by both genetic and environmental factors. In most patien...
Multiple sclerosis (MS) is a debilitating chronic disease characterized by inflammation, demyelination, axonal transection, and neurodegeneration in the central nervous system (CNS), leading to motor, sensory, and cognitive difficulties [1,2]. Although MS is thought to have an autoimmune component, o...
RESEARCH ARTICLE Long-Term Evolution of Multiple Sclerosis Disability in the Treatment Era University of California, San Francisco MS-EPIC Team: Bruce A. C. Cree, MD, PhD, MAS,1 Pierre-Antoine Gourraud, PhD, MPH,1 Jorge R. Oksenberg, PhD,1 Carolyn Bevan, MD, MS,1 Elizabeth Crabtree-...
Risk of multiple sclerosis after a first episode of central nervous system inflammatory demyelination in children from New South Wales, AustraliaTantsis, ETurvilleBrilot, FDale, R
This multicenter cohort study of patients with multiple sclerosis treated with autologous hematopoietic stem cell transplantation (AHSCT) evaluates the
ObjectiveTo reassess, in a cohort of patients with early-onset multiple sclerosis, the long-term evolution of cognitive deficits, their relationship to
Multiple sclerosis (MS) is the most common cause of neurological disability in young adults worldwide and approximately half of those affected are in Europe. The assessment of differential incidence and prevalence across populations can reveal spatial, t
An epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well established, but whether this reflects a shared genetic aetiology, and whether consistent genetic relationships exist between MS and the two predo
Multiple sclerosis (MS) is a chronic immune-mediated demyelinating and neurodegenerative disease, and the main disease-modifying treatments rely on modulation or suppression of the immune system Current results show that most drugs to treat MS are linked to an increased risk of infection to varying ...