In this study, we performed miRNA-seq and mRNA-seq on CD138 + cells isolated from bone marrow aspirates of 86 MM patients to identify novel interactions between sRNAs and mRNAs. We detected 9.8% significantly correlated miRNA-mRNA pairs of which 5.17% were positively correlated and 4.65%...
As MGA consists of finding and aligning homologous regions of the input genomes; a natural first step is identifying such regions. Pairwise local sequence alignment methods have been the prevailing technique to find and track homologous segments between genomes. First, all pairs of genomes are searc...
Due to its complex and multifaceted nature, developing effective treatments for epilepsy is still a major challenge. To deal with this complexity we introduce the concept of degeneracy to the field of epilepsy research: the ability of disparate elements
With a higher level of CXCL13, enhanced formation of osteoclasts and elevated receptor activator of nuclear kappa B ligand (RANKL) is observed, indicating the role of CXCL13 in osteolytic disease. In addition to lytic lesions, biopsies suggest the relationship between CXCL13 and extramedullary ...
Cruciferous plants have developed numerous molecular mechanisms to respond to various environmental and multiple biotic and abiotic stresses. Whenever plant encounters any kind of stress, first of all there is perception of the signals by the potential s
Genome rearrangement problems arise in both species evolution and cancer research. Basic genome rearrangement models assume that the genome contains a single copy of each gene and the only changes in the genome are structural, i.e., reordering of segment
Furthermore, DNA subcloning identified a novel sRNA located between waaQ and waaA ORFs, whose overexpression also induces the rpoEP-lacZ activity. Detailed analysis revealed that this sRNA is generated by the processing of 5′ UTR of the waaQ mRNA (see below). Additionally, overexpression of ...
The knowledge of the relationship between stress and infertility is still not broadly accepted. However, it has been reported that stress is a common factor in the development of unexplained reproductive disorders [9]. The major drawback seems to be the hardship in administering the correlation bet...
Multiphase drives offer enhanced fault-tolerant capabilities compared with conventional three-phase ones. Their phase redundancy makes them able to continue running in the event of faults (e.g., open/short-circuits) in certain phases. Moreover, their gre
After two days of anaerobic fermentation, the cells were shifted to aerobic conditions for another day. All strains formed the desired vitamin (Fig. 1A), whereby the B12 level ranged between 6.4 and 21.8 µg (100 g)−1. Vitamin B12 production in MRS medium was enhanced up to almost ...