Multiple myeloma, also known as Kahler's disease, is a type of blood cancer. There's no cure, but treatments can slow its spread and sometimes make symptoms go away. A type of white blood cell called a plasma cell makes antibodies that fight infections in your body. When you have multi...
blooddiagnosiscase-control studiesinflammatorymultiple myelomaprimary careBackgroundKoshiaris, ConstantinosVan den Bruel, AnnOke, Jason L.Nicholson, Brian D.Shephard, ElizabethBraddick, MickHamilton, WilliamUniv Oxford Nuffield Dept Primary Care Hlth Sci Radcliffe Primary Care Bldg Woodstock Rd Oxford...
Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. [1] MM is part of a spectrum of diseases ...
Although multiple myeloma affects the bones, it begins in blood cells, not bone cells.,Normal Cell (5%) Myeloma Cells (10-15%),an unusual amount of monoclonal (M) pr 3、otein. This protein may be called Bence Jones protein when it is found in the urine or an M-spike when found in...
外科学教学课件：Multiple Myeloma MultipleMyeloma MM 浆细胞病（plasmacelldyscrasia）是指浆细胞或产生免疫球蛋白的B淋巴过度增殖所引起的一组疾病，血清或尿中出现过量的单克隆免疫球蛋白或其轻链或重链片段为其特征的一组疾病。浆细胞病在临床上可分为两类：一类为具有明显临床症状和病理特征的恶性浆细胞病。另...
Improvement in renal function and its impact on survival in patients with newly diagnosed multiple myeloma. Blood Cancer J. 2015;5:e296. 44. Gonzalez-Osete G, Modiano M. Spinal cord compres- sion. In: Decision making in medicine. 1993. p. 292. Mosby Elsevier, Philadelphia. 45. Graham ...
Presenting signs and symptoms of multiple myeloma (MM) include bone pain, pathologic fractures, weakness, anemia, infection (often pneumococcal), hypercalcemia, spinal cord compression, and acute kidney injury. In approximately 30% of cases, MM is discovered through routine blood screening when patient...
Multiple myeloma is a blood cancer that occurs when white blood cells, called plasma cells, increase out of control in the bones. Myeloma destroys the bone by making osteoclasts – cells that break down old bones – become more active and weaken your bones. At the same time, myeloma cells ...
Multiple myeloma is a plasma cell blood cancer with frequent chromosomal translocations leading to gene fusions. To determine the clinical relevance of fusion events, we detect gene fusions from a cohort of 742 patients from the Multiple Myeloma Research
Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of treatment resistant disease. Defining how, when and where myeloma cell intrinsic and extrinsic bone microenvironmental mechanisms cause relapse is challenging wit