myeloma cell 骨髓瘤细胞 giant cell myeloma 巨细胞性骨髓瘤,巨细胞性骨髓瘤 相似单词 myeloma 骨髓瘤; 髓瘤 angio myeloma 血管骨髓瘤 multiple adj. 1.多个的;由多个部分组成的 2.许多的;多种多样的 3.多人享有的 4.多功能的;多职业的 5.【电】并联的;多路的 6.【植】聚花的 7.【英】连锁的...
Multiple myeloma (MM) is a biologically and clinically heterogeneous malignancy of terminally differentiated plasma cells (PCs), which abnormally proliferate in the bone marrow (BM), and typically secrete non-functional monoclonal immunoglobulin (Ig) in serum and urine. The stages of MM development us...
The BM plasma samples of 33 patients with MM and 27 controls were analyzed for OPG content by ELISA. We found that BM OPG levels were lower in MM patients (median 7.6 ng/mL; range 1.0-77.6 ng/mL) than in control patients (median, 10.4 ng/mL; range, 5.3-200 ng/mL; Figure 1A). ...
Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of plasma cells. Although therapeutic advances have been made to improve clinical outcomes and to prolong patients’ survival in the past two decades, MM remains largely incurable. Single-cell sequencing (SCS) is...
Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. [1] First described in 1848, MM is part of...
Multiple myeloma (MM) is a disease in which abnormal plasma cells proliferate and secrete monoclonal immunoglobulin in the bone marrow. The main characteristic of plasma cells is the expression of the cell surface antigen syndecan-1 (CD138). However,
Multiple myeloma (MM) is the second most common hematological malignancy in the US1, characterized by the clonal expansion of plasma cells localized primarily in the bone marrow microenvironment of the skeleton2,3. In the bone microenvironment, MM cells disrupt the finely tuned balance of trabecular...
Multiplemyelomais amalignancyof plasma cells, which are derived fromB lymphocytes(B cells) and are responsible for creating antibodies. The disease is characterized by infiltration of themyeloma cellsinto the bone and, eventually, other organs. These malignant cells produce monoclonal (M) proteins that...
Patients with multiple myeloma (MM) experience relapse and drug resistance; therefore, novel treatments are essential. Clotrimazole (CTZ) is a wide-spectrum antifungal drug with antitumor activity. However, CTZ’s effects on MM are unclear. We investigat
Multiple myeloma (MM) is a B-cell malignancy originating from pre-switched, follicle center B-lymphocytes which differentiate to plasma cells accumulating in the bone marrow. MM cells are characterized by a profound genetic instability resulting in a complex set of numerical and structural chromosomal...