Presenting signs and symptoms of multiple myeloma (MM) include bone pain, pathologic fractures, weakness, anemia, infection (often pneumococcal), hypercalcemia, spinal cord compression, and renal failure. In approximately 30% of cases, MM is discovered through routine blood screening when patients are...
multiple myeloma (SMM). These phenotypes lack myeloma-defining events (MDE), such as end-organ damage or amyloidosis. However, patients affected have an abnormally higher rate of monoclonal B cells in their bone marrow (MGUS, SMM) or elevated serum and urinary monoclonal protein that is a clas...
The commonly assumed target, RB1, showed complete LOF in 3.2% of patients, while DIS3 complete LOF was detected in 6.9% of patients; however, a striking number of additional genes were independently knocked out in myeloma (Fig. 1b). The following two contiguous gene regions with complete ...
Medical Specialties / Oncology / Multiple MyelomaDiscovery Medicine
This is an experimental project to detect Multiple-Myeloma from some pieces of tiled-images created from a large 4K image, by using our Tensorflow-Slightly-Flexible-UNet. The original dataset used here has been take from the following web site: SegPC-2021-dataset SegPC-2021: Segmentation of ...
This is an experimental project detect MultipleMyeloma by using TensorflowSwinUNetModel, which is a Tensorflow 2 implementation of Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation . In order to write the TensorflowSwinUNet Python class, we have used the Python code in the ...
The code generated during this study to analyze the single-cell datasets is available through GitHub at https://github.com/MyelomaRotterdam/Microenvironment. References Scrivo, R., Vasile, M., Bartosiewicz, I. & Valesini, G. Inflammation as ‘common soil’ of the multifactorial diseases. Autoimm...
Suzanne Trudel, MSc, MD, discusses key results and subgroup analyses from the phase 3 DREAMM-7 trial of BVd in relapsed/refractory multiple myeloma.
To investigate the role of employment history and workplace exposures as risk factors for multiple myeloma among women, a population-based case-control study using the Danish Cancer Registry data linkage system was conducted. All cases of myeloma diagnosed in Danish women between 1970 and 1984 (1...
Gene expression profiling (GEP) has significantly contributed to the elucidation of the molecular heterogeneity of multiple myeloma plasma cells (MMPC) and only recently it has been recommended for risk stratification. Prior to GEP MMPC need to be enriched resulting in an inability to immediately fr...