There is much evidence that Bacillus cereus in immunocompromised patients leads to a localized, necrotizing tissue infection due to the production of potent toxins and usually results in rapid and fulminant tissue destruction. Bacillus species has an special affinity for the CNS mediated by phospho...
24 h to brain ECs separately (Fig.2f). Solely, TNFα increased TRPV4 expression at both the RNA and protein level, while this effect was not observed with the concurrent addition of IFNγ (Fig.2f, g, Additional file1: Fig. S2f). To assess the functional consequence of TNF-induced TRPV...
This observation suggests that either some specific antigenic epitope among the RVLPs is necessary or a specific protein folding pattern which might not be achieved in insect cells when recombinantly produced or that the pathogenesis is localized to the CNS as argued for syncytin-1 [102], [134]...
Sib-pair analysis using polymorphic DNA variants initially localized the gene to chromosome 3 (3q22→24). Positional cloning revealed mutation in the winged helix/forkhead transcription factor gene (FOXL2), a truncated protein in each of four cases. Reported mutations include three cases with stop...
Introduction: With the diminishing use of whole-brain radiotherapy (WBRT), there is increasing debate regarding the maximum number of brain metastases that should be treated with stereotactic radiosurgery (SRS). In patients with >10-15 lesions,...
Focus on localized laryngeal amyloidosis: management of five cases Research Article NEAT1 aggravates sepsis-induced acute kidney injury by sponging miR-22-3p Pericentric inversion in chromosome 1 and male infertility Increased atherogenic index in the general hearing loss population Prognostic role...
(AVs) dynamics and function within dendrites. Stimulating synaptic activity inhibits AV movement in dendrites, thereby enhancing their degradability, whereas silencing synaptic activity has the opposite effect on AV function. This effect is localized and reversible and occurs in dendrites rather than ...
MM is associated with osteolytic bone lesions and skeletal complications [130]. Interactions between MM cells and BMSCs promote tumor growth, survival and bone destruction. Osteolytic lesions are localized to areas adjacent to tumor growth and are characterized by increased activity of osteoclastic bo...
Local injection of oncolytic virus (Tvec) may also improve survival in select patients with localized unresectable disease. IL-2 can result in significant durable responses, but in only about 5% of patients. 24 When should amputation be used in the management of locally advanced melanoma? R...
8B). Surprisingly, most FCF-treated platelets displayed unusual high-order microtubule structures with condensed microtubule filaments perfectly co-localized with hyper-polymerized septin filaments (Fig. 8C, indicated by arrows). These structures were observed in 52.8 ± 1.8 % of FCF-treated platelets...