Patients are identified as active at the time of relapses or new MRI lesions or not active. Primary progressive multiple sclerosis includes patients who were previously diagnosed with progressive-relapsing multiple sclerosis. As used herein, “secondary progressive multiple sclerosis” refers to a ...
Multiple myeloma (MM) remains an incurable disease and novel therapeutic agents/approaches are urgently needed. The PIM (Proviral insertion in murine malignancies) serine/threonine kinases have 3 isoforms: PIM1, PIM2, and PIM3. PIM kinases are engaged wi
In addition to DNA lesions, an increase in expression of genes related to cation/metal binding, membrane formation, and morphogenesis was also seen in zebrafish when exposed to 4.6 mg/L IONP that were coated in meso-2, 3-dimercaptosuccinic acid (DMSA) [75]. When the concentration of IONPs...